HitPredict

Interactor 1: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP

Interactor 2: IRAK4 (Q9NWZ3)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Gene: IRAK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

The method score is based on:

Property	Details
Experiments	18221795, 21903422
Identification Methods	protein complementation assay, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0009986 - cell surface and 3 others more... GO:0034142 - toll-like receptor 4 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	221
Hs

1	460

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024