HitPredict

Interactor 1: AP3S2 (P59780)
AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b)
Gene: AP3S2

Interactor 2: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	11926829, 35844135
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0098793 - presynapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 175
+	Hs
		574635 AP3S2_HUMAN (1-193): 1.69e-74: 224: 100.00		ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74
+	Hs
		574721 AP3S1_HUMAN (1-192): 2.48e-74: 223: 84.38		ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74
+	Hs
		887139 AP3S2_HUMAN (1-193): 1.69e-74: 224: 100.00		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		950672 AP3S1_HUMAN (1-192): 2.48e-74: 223: 84.38		ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12
+	Hs
		913025 AP3S1_HUMAN (1-192): 2.48e-74: 223: 84.38		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		897392 AP3S1_HUMAN (1-192): 2.48e-74: 223: 84.38		ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54
+	Hs
		574639 COPZ1_HUMAN (2-161): 4.71e-45: 148: 20.61		ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74
+	Hs
		902297 COPZ1_HUMAN (2-161): 4.71e-45: 148: 20.61		ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12
+	Hs
		902292 COPZ1_HUMAN (2-161): 4.71e-45: 148: 20.61		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Dm
		778371 Q8IQP2_DROME (5-161): 9.1e-16: 72.7: 14.72		ARF4_DROME (1-173): 3.53e-69: 209: 65.32