Protein: UHRF1
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)

Gene: UHRF1
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q96T88

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685055

DNMT1
DNA

21

20

Small-scale

0.990

High

1371626

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

15

8

Small-scale

0.987

High

998717

H31
Histone H3.1

18

20

Small-scale

0.979

High

1403642

UHRF1
E3 ubiquitin-protein ligase UHRF1

9

15

Small-scale

0.969

High

1162011

H31T
Histone H3.1t

9

20

Small-scale

0.968

High

906756

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.946

High

1403672

FBW1A
F-box/WD repeat-containing protein 1A

5

20

Small-scale

0.931

High

957176

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.915

High

1110016

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.886

High

1258923

H32
Histone H3.2

4

20

Small-scale

0.870

High

1403677

DNM3A
DNA

3

9

Small-scale

0.861

High

1017148

H33
Histone H3.3

3

20

Small-scale

0.834

High

1396285

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

9

Small-scale

0.827

High

551214

PCNA
Proliferating cell nuclear antigen

2

5

Small-scale

0.825

High

1403676

ARI1
E3 ubiquitin-protein ligase ARIH1

2

5

High-throughput

0.811

High

1399963

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

15

Small-scale

0.806

High

1403649

FACD2
Fanconi anemia group D2 protein

2

5

Small-scale

0.806

High

508485

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

12

Small-scale

0.778

High

260346

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.754

High

831286

CCNF
Cyclin-F

2

5

High-throughput

0.754

High

907546

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

7

Small-scale

0.754

High

981035

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1097515

CBX3
Chromobox protein homolog 3

2

19

Small-scale

0.754

High

1155688

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

Small-scale

0.754

High

920219

PLK1
Serine/threonine-protein kinase PLK1

1

6

Small-scale

0.747

High

1355988

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

Small-scale

0.747

High

1371252

KAT5
Histone acetyltransferase KAT5

6

6

Small-scale

0.742

High

436718

KPCB
Protein kinase C beta type

2

4

High-throughput

0.737

High

1143087

KPCD1
Serine/threonine-protein kinase D1

2

7

High-throughput

0.737

High

728398

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.724

High

1369198

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.724

High

617459

DNLI1
DNA ligase 1

5

9

Small-scale

0.713

High

487665

PARP1
Poly [ADP-ribose] polymerase 1

4

16

Small-scale

0.698

High

74579

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

14

High-throughput

0.691

High

322676

KDM4B
Lysine-specific demethylase 4B

1

14

High-throughput

0.691

High

502103

H2AZ
Histone H2A.Z

1

20

High-throughput

0.691

High

1163159

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1143851

TCAL1
Transcription elongation factor A protein-like 1

4

1

High-throughput

0.691

High

1403665

DNM3B
DNA

3

9

Small-scale

0.661

High

1133156

LASP1
LIM and SH3 domain protein 1

1

5

Small-scale

0.648

High

605790

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

8

Small-scale

0.647

High

957823

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

982295

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.647

High

372924

MYC
Myc proto-oncogene protein

3

16

Small-scale

0.640

High

1136103

PAF15
PCNA-associated factor

3

0

Small-scale

0.639

High

332572

CCDB1
Cyclin-D1-binding protein 1

3

0

High-throughput

0.638

High

414468

P53
Cellular tumor antigen p53

2

9

Small-scale

0.634

High

600048

ZNF18
Zinc finger protein 18

2

5

High-throughput

0.628

High

1250584

DPPA3
Developmental pluripotency-associated protein 3

2

2

High-throughput

0.621

High

157761

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

170303

AURKA
Aurora kinase A

1

9

Small-scale

0.618

High

216524

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

7

Small-scale

0.618

High

277790

H2AY
Core histone macro-H2A.1

1

20

Small-scale

0.618

High

401346

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

591802

H2AX
Histone H2AX

1

20

High-throughput

0.618

High

620536

NUCL
Nucleolin

1

14

Small-scale

0.618

High

674300

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

714371

PML
Protein PML

1

15

Small-scale

0.618

High

754953

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

799424

BRCA1
Breast cancer type 1 susceptibility protein

1

16

Small-scale

0.618

High

883666

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

891754

GSK3B
Glycogen synthase kinase-3 beta

1

7

Small-scale

0.618

High

1005007

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

Small-scale

0.618

High

1100279

TIF1B
Transcription intermediary factor 1-beta

1

16

Small-scale

0.618

High

1112671

CUL1
Cullin-1

1

10

Small-scale

0.618

High

1114088

CUL3
Cullin-3

1

11

High-throughput

0.618

High

1141277

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

1241749

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

Small-scale

0.618

High

1255187

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1380107

FBXW7
F-box/WD repeat-containing protein 7

1

16

High-throughput

0.618

High

1403256

RSF1
Remodeling and spacing factor 1

1

19

Small-scale

0.618

High

1403643

RING2
E3 ubiquitin-protein ligase RING2

1

19

High-throughput

0.618

High

1403648

RBM4
RNA-binding protein 4

1

11

Small-scale

0.618

High

1403659

LATS2
Serine/threonine-protein kinase LATS2

1

7

Small-scale

0.618

High

1403661

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.618

High

1403663

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

1403667

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1403669

FBW1B
F-box/WD repeat-containing protein 11

1

18

Small-scale

0.618

High

1403670

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.618

High

1027684

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

15

Small-scale

0.611

High

1208404

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

3

14

High-throughput

0.609

High

430262

JUN
Transcription factor Jun

2

8

Small-scale

0.584

High

559468

XRCC5
X-ray repair cross-complementing protein 5

2

13

Small-scale

0.584

High

846660

MSH2
DNA mismatch repair protein Msh2

2

5

Small-scale

0.584

High

913564

KIF11
Kinesin-like protein KIF11

1

5

Small-scale

0.578

High

1006646

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.575

High

1136844

MO4L2
Mortality factor 4-like protein 2

1

3

High-throughput

0.575

High

1209543

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.575

High

1328516

RNF10
E3 ubiquitin-protein ligase RNF10

1

3

High-throughput

0.575

High

1381848

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.575

High

1403664

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.575

High

282296

SAP30
Histone deacetylase complex subunit SAP30

1

3

Small-scale

0.561

High

331679

MBD4
Methyl-CpG-binding domain protein 4

1

4

Small-scale

0.561

High

404361

GCR
Glucocorticoid receptor

1

20

Small-scale

0.561

High

464392

ERCC1
DNA excision repair protein ERCC-1

1

1

Small-scale

0.561

High

542623

TOP2A
DNA topoisomerase 2-alpha

1

10

Small-scale

0.561

High

1399303

MUS81
Structure-specific endonuclease subunit MUS81

1

1

Small-scale

0.561

High

1403660

HELLS
Lymphoid-specific helicase

1

19

Small-scale

0.561

High

1403671

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.561

High

930025

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.553

High

1088208

MERTK
Tyrosine-protein kinase Mer

1

6

High-throughput

0.553

High

257170

CCD22
Coiled-coil domain-containing protein 22

1

3

High-throughput

0.536

High

601824

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

665679

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

2

High-throughput

0.536

High

682586

S100P
Protein S100-P

1

20

High-throughput

0.536

High

693919

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

854247

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

911353

IMA5
Importin subunit alpha-5

1

13

High-throughput

0.536

High

1065384

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1144137

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1218518

ZN691
Zinc finger protein 691

1

2

High-throughput

0.536

High

1383821

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1403653

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1403666

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

531129

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

2

High-throughput

0.521

High

1327784

SH2D3
SH2 domain-containing protein 3C

2

12

High-throughput

0.521

High

1247827

PADI6
Inactive protein-arginine deiminase type-6

1

0

High-throughput

0.513

High

1281453

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1403650

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1403662

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

0

High-throughput

0.513

High

540932

ERG
Transcriptional regulator ERG

1

20

Small-scale

0.501

High

1109495

ATR
Serine/threonine-protein kinase ATR

1

10

Small-scale

0.501

High

611956

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.489

High

1160730

DREB
Drebrin

1

4

High-throughput

0.489

High

1200325

ANR39
Ankyrin repeat domain-containing protein 39

1

10

High-throughput

0.489

High

1280215

MILR1
Allergin-1

1

1

High-throughput

0.489

High

1328580

FA24B
Protein FAM24B

1

1

High-throughput

0.489

High

1403675

HBS1L
HBS1-like protein

1

6

High-throughput

0.489

High

171921

ZN263
Zinc finger protein 263

1

4

Small-scale

0.479

High

218662

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

223274

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

243711

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

19

Small-scale

0.479

High

246890

KDM1A
Lysine-specific histone demethylase 1A

1

18

Small-scale

0.479

High

248056

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

396773

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

406539

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

408140

TBB4A
Tubulin beta-4A chain

1

15

Small-scale

0.479

High

442794

RB
Retinoblastoma-associated protein

1

4

Small-scale

0.479

High

457633

TBB5
Tubulin beta chain

1

15

Small-scale

0.479

High

461850

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

520314

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

558354

XRCC6
X-ray repair cross-complementing protein 6

1

13

Small-scale

0.479

High

607025

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

634593

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

657664

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

669979

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.479

High

711661

3MG
DNA-3-methyladenine glycosylase

1

1

Small-scale

0.479

High

785387

RL4
Large ribosomal subunit protein uL4

1

3

Small-scale

0.479

High

851647

GATA4
Transcription factor GATA-4

1

14

High-throughput

0.479

High

862398

YAP1
Transcriptional coactivator YAP1

1

7

Small-scale

0.479

High

913383

MSH6
DNA mismatch repair protein Msh6

1

8

Small-scale

0.479

High

927511

ATX1
Ataxin-1

1

2

High-throughput

0.479

High

937866

FOXA1
Hepatocyte nuclear factor 3-alpha

1

15

High-throughput

0.479

High

980191

H4
Histone H4

1

11

High-throughput

0.479

High

1024788

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1035858

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1106374

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

11

High-throughput

0.479

High

1124398

ELOA1
Elongin-A

1

11

Small-scale

0.479

High

1137474

SUZ12
Polycomb protein SUZ12

1

9

Small-scale

0.479

High

1137967

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

1156826

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

1334805

SERB1
SERPINE1 mRNA-binding protein 1

1

7

High-throughput

0.479

High

1339519

TET1
Methylcytosine dioxygenase TET1

1

1

Small-scale

0.479

High

1364218

TOPB1
DNA topoisomerase 2-binding protein 1

1

11

High-throughput

0.479

High

1369959

XPF
DNA repair endonuclease XPF

1

1

Small-scale

0.479

High

1383749

EME1
Structure-specific endonuclease subunit EME1

1

1

Small-scale

0.479

High

1403646

TCAB1
Telomerase Cajal body protein 1

1

20

Small-scale

0.479

High

1403647

TBB2B
Tubulin beta-2B chain

1

15

Small-scale

0.479

High

1403652

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1403656

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1403668

PARP2
Poly [ADP-ribose] polymerase 2

1

6

Small-scale

0.479

High

1403674

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

162671

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

1244820

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

191769

MAGB2
Melanoma-associated antigen B2

1

7

High-throughput

0.445

High

447340

NPM
Nucleophosmin

1

4

High-throughput

0.445

High

860902

RS10
Small ribosomal subunit protein eS10

1

6

High-throughput

0.445

High

1112137

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.445

High

1130401

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

1252501

LN28B
Protein lin-28 homolog B

1

8

High-throughput

0.445

High

1315246

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.445

High

1403655

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.445

High

1403673

YBOX2
Y-box-binding protein 2

1

8

High-throughput

0.445

High

272405

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

337015

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

Small-scale

0.437

High

346224

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

19

High-throughput

0.437

High

412482

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

1290345

SERC5
Serine incorporator 5

1

1

Small-scale

0.437

High

1403651

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.437

High

1403654

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1009294

PRR3
Proline-rich protein 3

1

0

High-throughput

0.426

High

1403645

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

578003

QCR7
Cytochrome b-c1 complex subunit 7

3

0

High-throughput

0.347

High

1403658

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

0

High-throughput

0.347

High

270114

TMCC2
Transmembrane and coiled-coil domains protein 2

2

0

High-throughput

0.328

High

1403657

MRM3
rRNA methyltransferase 3, mitochondrial

2

0

High-throughput

0.328

High

1372374

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

0

High-throughput

0.279

Low

1403644

PSD2
PH and SEC7 domain-containing protein 2

1

0

High-throughput

0.279

Low

1231280

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

Small-scale

0.249

Low

1398998

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025