HitPredict

Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: CADH8 (P55286)
Cadherin-8
Gene: CDH8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding GO:0045296 - cadherin binding GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 799
+	Mm
		486814 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH1_MOUSE (40-796): 0: 609: 32.52
+	Hs
		889951 PSN1_HUMAN (1-467): 0: 671: 100.00		CAD12_HUMAN (7-486): 1.07e-95: 317: 24.56
+	Hs
		618229 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH2_HUMAN (4-486): 1.37e-63: 231: 21.73
+	Mm
		580354 PSN1_MOUSE (1-467): 0: 650: 92.72		CADH2_MOUSE (4-486): 2.03e-64: 234: 21.47
+	Hs
		555958 PSN1_HUMAN (1-467): 0: 671: 100.00		CADH1_HUMAN (5-415): 1.82e-54: 204: 22.83