HitPredict

Interactor 1: SC61B (P60468)
Protein transport protein Sec61 subunit beta
Gene: SEC61B

Interactor 2: TMX1 (Q9H3N1)
Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene: TMX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 96 Hs			1 280
+	Hs
		890408 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		TMX4_HUMAN (20-261): 3.55e-53: 178: 41.98
+	Hs
		890351 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		TMX3_HUMAN (6-270): 4.15e-49: 170: 15.94
+	Hs
		890381 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		ERP44_HUMAN (1-161): 1.35e-38: 141: 23.12
+	Hs
		890162 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		PDIA6_HUMAN (25-146): 1.28e-34: 131: 31.01
+	Hs
		890147 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		PDIA5_HUMAN (5-228): 1.07e-33: 129: 14.58
+	Hs
		890268 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		TXND5_HUMAN (24-135): 1.06e-32: 126: 25.00
+	Hs
		531776 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		PDIA4_HUMAN (119-266): 7.26e-15: 76.3: 9.68
+	Hs
		890248 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		DJC10_HUMAN (64-264): 2.26e-14: 74.8: 10.95
+	Hs
		671770 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		PDIA3_HUMAN (147-256): 2.92e-14: 74.4: 12.61
+	Zm
		74708 B4FEC8_MAIZE (55-96): 1.53e-16: 69.5: 45.24		Q5EUD8_MAIZE (20-154): 1.1e-24: 104: 22.38
+	Hs
		423193 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		PDIA1_HUMAN (66-256): 1.82e-10: 62.8: 10.68