HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	21617041, 31723608, 37219487
Identification Methods	pull down, proximity labelling technology, unspecified method, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005737 - cytoplasm GO:0005776 - autophagosome GO:0005794 - Golgi apparatus GO:0005829 - cytosol and 1 others more... GO:0006914 - autophagy
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 577
+	Hs
		306267 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287376 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287366 MLP3C_HUMAN (5-116): 5.09e-45: 144: 42.11		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287379 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287372 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Mm
		1225237 MLP3A_MOUSE (5-117): 2.01e-45: 144: 41.74		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		502871 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64
+	Hs
		551651 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		1051455 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		305947 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		551832 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		725011 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		551835 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		551829 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60