HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: ATG3 (Q9NT62)
Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)
Gene: ATG3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	16303767, 33961781, 35271311, 20562859, 17353931
Identification Methods	enzymatic study, pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000045 - autophagosome assembly GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015031 - protein transport
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 314
+	Hs
		306334 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1328043 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Mm
		1265087 MLP3A_MOUSE (5-117): 2.01e-45: 144: 41.74		ATG3_MOUSE (1-314): 2.92e-158: 446: 97.45
+	Hs
		1315807 MLP3C_HUMAN (5-116): 5.09e-45: 144: 42.11		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1330642 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1326176 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		61904 MP3B2_HUMAN (2-117): 3.99e-43: 139: 37.29		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	At
		1013368 ATG8F_ARATH (2-117): 1.18e-61: 185: 62.07		ATG3_ARATH (17-314): 8.92e-122: 353: 46.41
+	Ce
		999358 LGG1_CAEEL (1-116): 2.15e-55: 170: 57.76		Q9N369_CAEEL (1-314): 2.55e-119: 347: 49.22
+	Ce
		1095400 LGG2_CAEEL (4-116): 6.38e-39: 128: 39.13		Q9N369_CAEEL (1-314): 2.55e-119: 347: 49.22
+	Pf
		83078 Q8IJK2_PLAF7 (4-116): 1.74e-47: 149: 40.98		C0H519_PLAF7 (3-314): 9.8e-111: 325: 37.11
+	Sc
		745998 ATG8_YEAST (1-116): 1.06e-58: 178: 56.03		ATG3_YEAST (8-311): 1.53e-97: 291: 33.13
+	Hs
		891316 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		306312 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		1328025 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Mm
		1246814 MLP3B_MOUSE (2-116): 2.53e-44: 141: 38.46		ATG10_MOUSE (173-301): 3.9e-44: 151: 20.59
+	Hs
		1315801 MLP3C_HUMAN (5-116): 5.09e-45: 144: 42.11		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		1326136 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		61902 MP3B2_HUMAN (2-117): 3.99e-43: 139: 37.29		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59