Protein: A1ZAN6
Rho guanine nucleotide exchange factor 2, isoform D (Rho guanine nucleotide exchange factor 2, isoform F)

Gene: A1ZAN6, RhoGEF2
Organism: Drosophila melanogaster
Interactions: 24
UniProt ID: A1ZAN6

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005826 - actomyosin contractile ring

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

57044

RHO1
Ras-like GTP-binding protein Rho1

2

20

Small-scale

0.713

High

57040

O96692
small monomeric GTPase

1

8

High-throughput

0.625

High

57043

CDC42
Cdc42 homolog

1

20

Small-scale

0.618

High

57045

DSH
Segment polarity protein dishevelled

1

20

Small-scale

0.618

High

57046

GRAP
Growth factor receptor-bound protein 2

1

19

High-throughput

0.618

High

57041

SGG
Protein kinase shaggy

1

8

High-throughput

0.575

High

57054

Q9BN17
Echinoid

1

3

High-throughput

0.575

High

57055

SMUF1
E3 ubiquitin-protein ligase Smurf1

1

7

High-throughput

0.575

High

57056

Q9VBA5
GM18993p

2

0

Small-scale

0.559

High

57053

HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

High-throughput

0.494

High

57048

SEM1A
Semaphorin-1A

1

2

High-throughput

0.489

High

57038

M9PD17
Gigas, isoform B

1

4

High-throughput

0.479

High

57051

Q7KUQ6
Limpet, isoform K

1

18

High-throughput

0.479

High

57052

FOXO
Forkhead box protein O

1

1

High-throughput

0.479

High

57057

Q9VCC9
LD23779p

1

15

High-throughput

0.479

High

57061

Q9XYR0
LD20987p

1

5

Small-scale

0.479

High

57050

SO
Protein sine oculis

1

1

High-throughput

0.464

High

57059

Q9VME5
Slow as molasses, isoform B

1

0

Small-scale

0.458

High

57039

TENM
Teneurin-m

1

6

High-throughput

0.445

High

57042

ARM
Armadillo segment polarity protein

1

5

High-throughput

0.445

High

57060

Q9VX92
Rho GTPase activating protein at 15B, isoform C

1

3

High-throughput

0.445

High

57047

Q0E8S4
Semaphorin-1A

1

2

High-throughput

0.407

High

57049

NETB
Netrin-B

1

2

High-throughput

0.407

High

57058

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025