HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	28661476, 24276241
Identification Methods	enzymatic study, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 618
+	Hs
		925256 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		900447 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		925255 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		893976 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		900446 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Mm
		925796 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		XIAP_MOUSE (20-173): 1.62e-31: 130: 28.66
+	Hs
		900385 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		925191 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		893899 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		545321 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		892316 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Dm
		776886 RAC1_DROME (1-191): 1.02e-81: 242: 69.27		DIAP1_DROME (35-174): 2.28e-22: 102: 23.57