Protein: SPY2
Protein sprouty homolog 2 (Spry-2)

Gene: SPY2, SPRY2
Organism: Homo sapiens
Interactions: 150
UniProt ID: O43597

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

221083

CBL
E3 ubiquitin-protein ligase CBL

19

7

Small-scale

0.767

High

221115

GRB2
Growth factor receptor-bound protein 2

7

15

Small-scale

0.748

High

221168

SH3K1
SH3 domain-containing kinase-binding protein 1

3

19

Small-scale

0.680

High

221064

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

3

High-throughput

0.678

High

221106

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

3

14

High-throughput

0.674

High

221153

ZDH17
Palmitoyltransferase ZDHHC17

5

10

High-throughput

0.664

High

221174

KR412
Keratin-associated protein 4-12

2

20

High-throughput

0.646

High

221089

OTX1
Homeobox protein OTX1

2

3

High-throughput

0.640

High

221071

GRAP2
GRB2-related adapter protein 2

2

20

High-throughput

0.633

High

221120

MTG8
Protein CBFA2T1

2

1

High-throughput

0.633

High

221158

CTSR1
Cation channel sperm-associated protein 1

2

4

High-throughput

0.633

High

221060

SPY1
Protein sprouty homolog 1

2

15

Small-scale

0.631

High

221141

LCE1B
Late cornified envelope protein 1B

3

6

High-throughput

0.617

High

221114

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

1

High-throughput

0.611

High

221068

SNX3
Sorting nexin-3

2

0

High-throughput

0.585

High

221128

PLSI
Plastin-1

2

0

High-throughput

0.585

High

221116

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

1

Small-scale

0.584

High

221183

SPY4
Protein sprouty homolog 4

2

15

Small-scale

0.584

High

221185

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.578

High

221145

TENS2
Tensin-2

2

1

High-throughput

0.576

High

220212

FRS3
Fibroblast growth factor receptor substrate 3

1

1

High-throughput

0.573

High

221062

NCK2
Cytoplasmic protein NCK2

1

15

High-throughput

0.573

High

221070

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.573

High

221084

KRA59
Keratin-associated protein 5-9

1

20

High-throughput

0.573

High

221085

GRN
Progranulin

1

4

High-throughput

0.573

High

221086

AQP1
Aquaporin-1

1

3

High-throughput

0.573

High

221097

MEOX2
Homeobox protein MOX-2

1

10

High-throughput

0.573

High

221111

KR108
Keratin-associated protein 10-8

1

20

High-throughput

0.573

High

221112

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.573

High

221117

CREB5
Cyclic AMP-responsive element-binding protein 5

1

4

High-throughput

0.573

High

221134

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

2

High-throughput

0.573

High

221160

ZN417
Zinc finger protein 417

1

9

High-throughput

0.573

High

221162

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.573

High

221170

HEXI2
Protein HEXIM2

1

2

High-throughput

0.573

High

221171

ZN587
Zinc finger protein 587

1

8

High-throughput

0.573

High

221173

MDFI
MyoD family inhibitor

1

2

High-throughput

0.573

High

221179

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.573

High

221180

KRA92
Keratin-associated protein 9-2

1

20

High-throughput

0.573

High

221181

KR411
Keratin-associated protein 4-11

1

20

High-throughput

0.573

High

221190

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

1

High-throughput

0.573

High

221196

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

2

High-throughput

0.573

High

221198

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

1

2

High-throughput

0.573

High

221199

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.573

High

221081

BRAF
Serine/threonine-protein kinase B-raf

1

3

Small-scale

0.561

High

221095

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

Small-scale

0.561

High

221119

KPCD
Protein kinase C delta type

1

1

Small-scale

0.561

High

221177

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

3

Small-scale

0.561

High

221069

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

221078

ACHG
Acetylcholine receptor subunit gamma

1

0

High-throughput

0.549

High

221080

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.549

High

221093

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

High-throughput

0.549

High

221146

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.549

High

221166

ATRIP
ATR-interacting protein

1

0

High-throughput

0.549

High

221202

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.549

High

221059

SPY2
Protein sprouty homolog 2

1

14

High-throughput

0.541

High

221099

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

221100

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

221123

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.541

High

221124

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.541

High

221149

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.541

High

221130

KPCD1
Serine/threonine-protein kinase D1

1

0

Small-scale

0.537

High

221105

CAV3
Caveolin-3

1

1

High-throughput

0.536

High

221152

ZDH13
Palmitoyltransferase ZDHHC13

1

10

High-throughput

0.536

High

221193

TES
Testin

1

3

High-throughput

0.536

High

221175

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

Small-scale

0.529

High

221066

MABP1
Mitogen-activated protein kinase-binding protein 1

1

2

High-throughput

0.523

High

221129

LASP1
LIM and SH3 domain protein 1

1

4

High-throughput

0.523

High

221136

LCE3C
Late cornified envelope protein 3C

1

1

High-throughput

0.523

High

221137

LCE3E
Late cornified envelope protein 3E

1

6

High-throughput

0.523

High

221142

LCE4A
Late cornified envelope protein 4A

1

1

High-throughput

0.523

High

221143

LCE2D
Late cornified envelope protein 2D

1

4

High-throughput

0.523

High

221186

CHRD
Chordin

1

8

High-throughput

0.523

High

221195

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

2

High-throughput

0.523

High

180452

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

221065

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.518

High

221075

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

Small-scale

0.515

High

221110

KR105
Keratin-associated protein 10-5

1

20

High-throughput

0.515

High

221113

KR10B
Keratin-associated protein 10-11

1

20

High-throughput

0.515

High

221182

KRA47
Keratin-associated protein 4-7

1

20

High-throughput

0.515

High

221090

CGL
Cystathionine gamma-lyase

1

0

High-throughput

0.513

High

221161

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

High-throughput

0.513

High

221172

S10AD
Protein S100-A13

1

0

High-throughput

0.513

High

221067

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.508

High

221076

CYTB
Cystatin-B

1

1

High-throughput

0.508

High

221098

DYN2
Dynamin-2

1

1

High-throughput

0.508

High

221103

NR1H2
Oxysterols receptor LXR-beta

1

5

High-throughput

0.508

High

221118

ZBT16
Zinc finger and BTB domain-containing protein 16

1

8

High-throughput

0.508

High

221126

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.508

High

221127

ZN266
Zinc finger protein 266

1

3

High-throughput

0.508

High

221155

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.508

High

211519

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.501

High

221122

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.494

High

221148

ATL4
ADAMTS-like protein 4

1

4

High-throughput

0.494

High

221176

TRI51
Tripartite motif-containing protein 51

1

2

High-throughput

0.494

High

221187

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.493

High

221082

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.486

High

221102

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.486

High

221178

RTF2
Replication termination factor 2

1

0

High-throughput

0.486

High

221192

SEM5B
Semaphorin-5B

1

0

High-throughput

0.486

High

221072

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.481

High

221096

HXA1
Homeobox protein Hox-A1

1

16

High-throughput

0.481

High

221104

AF17
Protein AF-17

1

2

High-throughput

0.481

High

221108

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.481

High

221109

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.481

High

221125

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

221132

ITSN1
Intersectin-1

1

1

High-throughput

0.481

High

221140

LCE1A
Late cornified envelope protein 1A

1

3

High-throughput

0.481

High

221157

TXND5
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.481

High

221164

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

1

High-throughput

0.481

High

221201

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

169338

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.479

High

221061

SPY3
Protein sprouty homolog 3

1

15

Small-scale

0.479

High

221073

RASH
GTPase HRas

1

8

Small-scale

0.479

High

221074

RASK
GTPase KRas

1

10

High-throughput

0.479

High

221092

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

221094

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

221121

SOS1
Son of sevenless homolog 1

1

5

Small-scale

0.479

High

221131

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

221159

VANG1
Vang-like protein 1

1

1

High-throughput

0.479

High

221163

FRS2
Fibroblast growth factor receptor substrate 2

1

1

Small-scale

0.479

High

221167

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

1

High-throughput

0.479

High

221169

EGLN2
Prolyl hydroxylase EGLN2

1

2

Small-scale

0.479

High

221184

EGLN1
Egl nine homolog 1

1

2

Small-scale

0.479

High

221188

EGLN3
Prolyl hydroxylase EGLN3

1

2

Small-scale

0.479

High

221197

VANG2
Vang-like protein 2

1

1

High-throughput

0.479

High

221200

CAB39
Calcium-binding protein 39

1

1

High-throughput

0.479

High

221135

Q5JPT6
SH3 domain-containing kinase-binding protein 1

1

19

High-throughput

0.470

High

221147

Q6P2C6
MLLT6 protein

1

3

High-throughput

0.470

High

221150

Q86UY0
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.470

High

221079

CATB
Cathepsin B

1

1

High-throughput

0.464

High

221091

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

3

High-throughput

0.464

High

221101

CRIP2
Cysteine-rich protein 2

1

2

High-throughput

0.464

High

221151

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

Small-scale

0.460

High

221087

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.458

High

221133

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

221144

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

221194

CTNA3
Catenin alpha-3

1

0

Small-scale

0.458

High

221165

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

221138

LCE1C
Late cornified envelope protein 1C

1

7

High-throughput

0.439

High

221139

LCE1F
Late cornified envelope protein 1F

1

3

High-throughput

0.439

High

221156

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.439

High

221107

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

221203

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

221191

FAIM1
Fas apoptotic inhibitory molecule 1

1

0

High-throughput

0.299

High

221063

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.279

Low

221077

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

221088

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

221154

F219A
Protein FAM219A

1

0

High-throughput

0.265

Low

221189

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025