Protein: SPY1
Protein sprouty homolog 1 (Spry-1)

Gene: SPY1, SPRY1
Organism: Homo sapiens
Interactions: 110
UniProt ID: O43609

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0001656 - metanephros development
GO:0001657 - ureteric bud development
GO:0001759 - organ induction
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

221339

KR107
Keratin-associated protein 10-7

3

20

High-throughput

0.675

High

221340

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.675

High

221341

KR109
Keratin-associated protein 10-9

3

20

High-throughput

0.675

High

221333

GEMI4
Gem-associated protein 4

4

0

Small-scale

0.654

High

221316

CBL
E3 ubiquitin-protein ligase CBL

3

7

Small-scale

0.650

High

221324

HXA1
Homeobox protein Hox-A1

4

16

High-throughput

0.639

High

221367

LCE2D
Late cornified envelope protein 2D

4

4

High-throughput

0.637

High

221336

KR101
Keratin-associated protein 10-1

3

20

High-throughput

0.635

High

221060

SPY2
Protein sprouty homolog 2

2

15

Small-scale

0.631

High

221391

MDFI
MyoD family inhibitor

3

2

High-throughput

0.619

High

221344

CREB5
Cyclic AMP-responsive element-binding protein 5

3

4

High-throughput

0.616

High

209862

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

1

High-throughput

0.615

High

221393

LCE3D
Late cornified envelope protein 3D

2

6

High-throughput

0.615

High

221326

MEOX2
Homeobox protein MOX-2

3

10

High-throughput

0.609

High

221374

NT2NA
Notch homolog 2 N-terminal-like protein A

3

3

High-throughput

0.609

High

221306

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

3

High-throughput

0.606

High

221307

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

221317

FBLN1
Fibulin-1

2

5

High-throughput

0.606

High

221319

KRA59
Keratin-associated protein 5-9

2

20

High-throughput

0.606

High

221331

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.606

High

221332

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

14

High-throughput

0.606

High

221334

KR122
Keratin-associated protein 12-2

2

20

High-throughput

0.606

High

221335

KR123
Keratin-associated protein 12-3

2

2

High-throughput

0.606

High

221347

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.606

High

221350

K1H1
Keratin, type I cuticular Ha1

2

2

High-throughput

0.606

High

221361

LCE1A
Late cornified envelope protein 1A

2

3

High-throughput

0.606

High

221378

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.606

High

221383

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

3

High-throughput

0.606

High

221392

KR412
Keratin-associated protein 4-12

2

20

High-throughput

0.606

High

221394

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.606

High

221395

KRA92
Keratin-associated protein 9-2

2

20

High-throughput

0.606

High

221402

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

2

2

High-throughput

0.606

High

180180

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

221345

REL
Proto-oncogene c-Rel

2

0

High-throughput

0.580

High

221348

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

221377

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

221397

KRA32
Keratin-associated protein 3-2

2

0

High-throughput

0.580

High

221399

NTRI
Neurotrimin

2

0

High-throughput

0.580

High

221404

ZN330
Zinc finger protein 330

2

0

High-throughput

0.580

High

221362

LCE1B
Late cornified envelope protein 1B

2

6

High-throughput

0.578

High

221320

OTX1
Homeobox protein OTX1

2

3

High-throughput

0.573

High

221388

HEXI2
Protein HEXIM2

1

2

High-throughput

0.573

High

221396

KRA42
Keratin-associated protein 4-2

1

20

High-throughput

0.573

High

221313

ZNF23
Zinc finger protein 23

2

3

High-throughput

0.561

High

221363

LCE3A
Late cornified envelope protein 3A

2

3

High-throughput

0.561

High

221352

CCD57
Coiled-coil domain-containing protein 57

2

1

High-throughput

0.553

High

221353

VWC2
Brorin

2

3

High-throughput

0.553

High

221354

LCE3C
Late cornified envelope protein 3C

2

1

High-throughput

0.553

High

221356

KPRP
Keratinocyte proline-rich protein

2

2

High-throughput

0.553

High

221357

LCE1C
Late cornified envelope protein 1C

2

7

High-throughput

0.553

High

221360

LCE1F
Late cornified envelope protein 1F

2

3

High-throughput

0.553

High

221364

LCE4A
Late cornified envelope protein 4A

2

1

High-throughput

0.553

High

221365

LCE2A
Late cornified envelope protein 2A

2

3

High-throughput

0.553

High

221366

LCE2C
Late cornified envelope protein 2C

2

4

High-throughput

0.553

High

221368

LCE5A
Late cornified envelope protein 5A

2

1

High-throughput

0.553

High

221369

FHL5
Four and a half LIM domains protein 5

2

5

High-throughput

0.553

High

221373

ATL4
ADAMTS-like protein 4

2

4

High-throughput

0.553

High

221379

M21D2
Nucleotidyltransferase MB21D2

2

3

High-throughput

0.553

High

221380

ZN441
Zinc finger protein 441

2

2

High-throughput

0.553

High

221381

ZN417
Zinc finger protein 417

2

9

High-throughput

0.553

High

221386

ZN837
Zinc finger protein 837

2

7

High-throughput

0.553

High

221390

TGM7
Protein-glutamine gamma-glutamyltransferase Z

2

2

High-throughput

0.553

High

221398

CHRD
Chordin

2

8

High-throughput

0.553

High

221327

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

221328

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

221403

R3HD2
R3H domain-containing protein 2

1

2

High-throughput

0.523

High

221343

GRB2
Growth factor receptor-bound protein 2

1

15

Small-scale

0.515

High

221338

KR105
Keratin-associated protein 10-5

1

20

High-throughput

0.515

High

221342

KR10B
Keratin-associated protein 10-11

1

20

High-throughput

0.515

High

139665

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

1

High-throughput

0.508

High

184661

ATX7
Ataxin-7

1

1

High-throughput

0.508

High

221318

TYY1
Transcriptional repressor protein YY1

1

12

High-throughput

0.481

High

221337

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.481

High

221372

ANR11
Ankyrin repeat domain-containing protein 11

1

3

High-throughput

0.481

High

217555

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

221309

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

221312

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

221314

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

Small-scale

0.479

High

221315

RASA1
Ras GTPase-activating protein 1

1

10

Small-scale

0.479

High

221322

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

221323

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

Small-scale

0.479

High

221329

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.479

High

221349

CBLB
E3 ubiquitin-protein ligase CBL-B

1

7

Small-scale

0.479

High

221351

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

221371

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

221385

SH3K1
SH3 domain-containing kinase-binding protein 1

1

19

Small-scale

0.479

High

221387

DRC1
Dynein regulatory complex protein 1

1

2

High-throughput

0.479

High

221400

AMFR
E3 ubiquitin-protein ligase AMFR

1

6

Small-scale

0.479

High

221401

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

221311

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.470

High

221370

Q6FHY5
MEOX2 protein

1

11

High-throughput

0.470

High

221405

X5D778
Ankyrin repeat domain 11 isoform A

1

2

High-throughput

0.470

High

221310

HRG
Histidine-rich glycoprotein

1

0

High-throughput

0.460

High

221321

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.460

High

221330

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

159424

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

220323

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

221346

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

1

Small-scale

0.445

High

221355

LCE3E
Late cornified envelope protein 3E

1

6

High-throughput

0.439

High

221359

LCE1E
Late cornified envelope protein 1E

1

4

High-throughput

0.439

High

221382

SOCS4
Suppressor of cytokine signaling 4

1

8

High-throughput

0.439

High

70043

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

221308

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

221325

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

221358

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

221375

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

221376

CDR2L
Cerebellar degeneration-related protein 2-like

2

0

High-throughput

0.316

High

221389

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

447

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

221384

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025