HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: Q8IXW7 (Q8IXW7)
FMR1 protein (Fragile X messenger ribonucleoprotein 1) (Truncated FMRP)
Gene: FMR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	unassigned1304, 24722188
Identification Methods	validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Agenet~Agenet, Agenet~KH_9, Agenet~Tudor_FRX1, KH_1~KH_1, KH_9~Tudor_FRX1
Common GO terms	GO:0005737 - cytoplasm GO:0098794 - postsynapse
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 297
+	Hs
		899787 FXR2_HUMAN (1-673): 0: 1004: 100.00		FXR1_HUMAN (1-294): 0: 536: 74.15
+	Hs
		900288 FXR2_HUMAN (1-673): 0: 1004: 100.00		FMR1_HUMAN (1-294): 0: 531: 100.00
+	Mm
		1223031 Q6P5B5_MOUSE (1-673): 0: 995: 97.19		FXR1_MOUSE (1-294): 0: 535: 73.81
+	Mm
		1242717 Q6P5B5_MOUSE (1-673): 0: 995: 97.19		Q8BPK8_MOUSE (1-294): 0: 524: 98.64
+	Hs
		900252 FXR2_HUMAN (1-673): 0: 1004: 100.00		FXR2_HUMAN (4-294): 1.01e-179: 513: 71.48
+	Mm
		777902 FXR1_MOUSE (14-673): 0: 981: 62.83		FMR1_MOUSE (1-294): 0: 531: 98.64
+	Mm
		1223056 FXR1_MOUSE (14-673): 0: 981: 62.83		Q8BPK8_MOUSE (1-294): 0: 524: 98.64
+	Mm
		778020 FXR2_MOUSE (1-673): 0: 959: 94.52		FMR1_MOUSE (1-294): 0: 531: 98.64
+	Mm
		1223108 FXR1_MOUSE (14-673): 0: 981: 62.83		FXR2_MOUSE (4-294): 4.76e-176: 503: 70.10
+	Hs
		899786 FXR1_HUMAN (14-673): 0: 798: 51.34		FXR1_HUMAN (1-294): 0: 536: 74.15
+	Hs
		900025 FXR1_HUMAN (14-673): 0: 798: 51.34		Q8IXW7_HUMAN (1-297): 0: 536: 100.00
+	Hs
		899852 FXR1_HUMAN (14-673): 0: 798: 51.34		FMR1_HUMAN (1-294): 0: 531: 100.00
+	Dm
		1445514 FMR1_DROME (14-642): 0: 599: 34.58		FMR1_DROME (1-294): 1.47e-154: 449: 44.63