HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG29 (Q52LW3)
Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)
Gene: ARHGAP29

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1261
+	Hs
		900997 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GMIP_HUMAN (129-1073): 6.62e-146: 468: 31.44
+	Hs
		900637 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SRGP1_HUMAN (176-1241): 1.8e-141: 459: 13.72
+	Mm
		1265268 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		SRGP1_MOUSE (176-1241): 3.16e-134: 439: 13.46
+	Sc
		419696 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		RGA1_YEAST (144-885): 8.96e-83: 295: 13.52
+	Sc
		419681 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		LRG1_YEAST (89-890): 1.62e-68: 252: 15.02
+	Hs
		64681 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG32_HUMAN (603-1226): 1.47e-75: 278: 17.39
+	Hs
		49631 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG10_HUMAN (284-1100): 1.95e-77: 275: 14.39
+	Hs
		245183 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OPHN1_HUMAN (284-1103): 8.23e-77: 273: 14.14
+	Hs
		900443 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9B_HUMAN (575-1128): 1.14e-70: 263: 17.61
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (529-1114): 2.51e-70: 262: 16.64
+	Hs
		901006 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG20_HUMAN (644-1188): 3.9e-70: 259: 18.00
+	Hs
		70663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9A_HUMAN (562-1127): 3.13e-67: 252: 15.82
+	Hs
		900954 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG35_HUMAN (484-914): 2.77e-67: 252: 18.97
+	Hs
		900426 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ABR_HUMAN (668-867): 6.46e-19: 95.1: 31.68
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (668-867): 9.49e-19: 94.4: 31.68
+	Hs
		901000 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG23_HUMAN (680-886): 1.7e-17: 90.9: 31.43
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (668-853): 1.47e-16: 87.8: 32.98
+	Hs
		901048 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG26_HUMAN (682-887): 1.1e-15: 84.3: 28.77
+	Mm
		1125742 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RHG01_MOUSE (669-886): 1.77e-15: 82.4: 26.70
+	Mm
		925791 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG01_MOUSE (669-886): 1.77e-15: 82.4: 26.70