HitPredict

Interactor 1: RND3 (P61587)
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Gene: RND3

Interactor 2: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0007165 - signal transduction GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 244 Hs			1 508
+	Hs
		852543 RND2_HUMAN (20-244): 3.9e-103: 300: 64.00		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		647849 RND2_HUMAN (20-244): 3.9e-103: 300: 64.00		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		852529 RND2_HUMAN (20-244): 3.9e-103: 300: 64.00		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		830313 RND2_HUMAN (20-244): 3.9e-103: 300: 64.00		KC1E_HUMAN (21-455): 3.27e-110: 335: 23.06
+	Hs
		436388 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		1205041 RND1_HUMAN (1-244): 1.22e-90: 268: 58.20		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		852699 RND2_HUMAN (20-244): 3.9e-103: 300: 64.00		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		436165 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		436371 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		1183082 RND1_HUMAN (1-244): 1.22e-90: 268: 58.20		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		647936 RND1_HUMAN (1-244): 1.22e-90: 268: 58.20		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		647867 RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		915778 RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		436148 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		647859 RND3_HUMAN (1-244): 1.15e-81: 246: 100.00		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		901189 RND3_HUMAN (1-244): 1.15e-81: 246: 100.00		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		436599 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		916109 RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		821973 RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84		KC1A_HUMAN (17-366): 5.32e-106: 321: 24.72
+	Hs
		568605 CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45