Interactor 1: H3 (P61830)
Histone H3
Gene: HHT1
Interactor 2: DOT1 (Q04089)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1
Species: Saccharomyces cerevisiae S288C
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12080090, 12097318, 12086673, 25965993, 29339748, 18158898, 33479126, 18511943, 20678485 |
| Identification Methods | biochemical, affinity chromatography technology, enzymatic study, pull down, x-ray crystallography |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DOT1~Histone |
| Common GO terms | GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0070911 - global genome nucleotide-excision repair |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
