HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 677
+	Hs
		903281 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		863397 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		COPA_HUMAN (261-665): 6.18e-29: 125: 10.07
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Hs
		725410 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		COPB2_HUMAN (495-675): 3.92e-22: 103: 14.67
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (536-664): 1.93e-19: 91.8: 15.39
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (571-658): 2.46e-14: 77.9: 20.23
+	Hs
		903174 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		TBL3_HUMAN (239-675): 4.54e-13: 74.8: 6.36
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		209416 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PLRG1_HUMAN (443-617): 2.25e-10: 65.7: 12.99
+	Hs
		793040 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (486-675): 1.02e-24: 109: 11.00
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (525-671): 1.08e-20: 96.4: 11.18
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (3-74): 3.87e-12: 70.6: 18.06
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		245633 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1X_HUMAN (84-378): 1.85e-27: 119: 10.65