Protein: SUZ12
Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog)

Gene: SUZ12
Organism: Mus musculus
Interactions: 30
UniProt ID: Q80U70

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0001739 - sex chromatin
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222434

EZH2
Histone-lysine N-methyltransferase EZH2

9

11

Small-scale

0.970

High

1281983

EED
Polycomb protein EED

6

8

Small-scale

0.943

High

1000271

EZH1
Histone-lysine N-methyltransferase EZH1

3

11

Small-scale

0.847

High

1222070

RBBP4
Histone-binding protein RBBP4

2

6

Small-scale

0.754

High

1222093

RBBP7
Histone-binding protein RBBP7

2

7

Small-scale

0.754

High

1224041

JARD2
Protein Jumonji

7

6

Small-scale

0.747

High

1231049

Q6AXH7
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.691

High

1036635

MTF2
Metal-response element-binding transcription factor 2

3

6

Small-scale

0.656

High

1274388

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

3

2

Small-scale

0.656

High

1281988

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

Small-scale

0.586

High

1281986

PHF19
PHD finger protein 19

2

6

Small-scale

0.584

High

1281990

AEBP2
Zinc finger protein AEBP2

2

3

Small-scale

0.584

High

312443

DNM3B
DNA

2

4

Small-scale

0.571

High

877627

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

3

Small-scale

0.536

High

1190990

KDM5A
Lysine-specific demethylase 5A

1

6

Small-scale

0.501

High

1281979

SUZ12
Polycomb protein Suz12

1

1

Small-scale

0.479

High

1281980

ASXL2
Putative Polycomb group protein ASXL2

1

2

Small-scale

0.479

High

1281981

SMC5
Structural maintenance of chromosomes protein 5

1

4

Small-scale

0.479

High

1281984

FOXP3
Forkhead box protein P3

1

1

High-throughput

0.479

High

1281989

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.479

High

108736

G3X9H5
Huntingtin

1

0

Small-scale

0.458

High

1281982

ELF5
ETS-related transcription factor Elf-5

1

0

High-throughput

0.458

High

312428

DNM3A
DNA

1

4

Small-scale

0.445

High

568893

DNMT1
DNA

1

3

Small-scale

0.445

High

1027940

TYY1
Transcriptional repressor protein YY1

1

1

Small-scale

0.445

High

1204083

Q5DTP7
Chromodomain-helicase-DNA-binding protein 4

1

8

High-throughput

0.445

High

1223204

HIRA
Protein HIRA

1

3

Small-scale

0.445

High

1281985

DNM3L
DNA

1

3

Small-scale

0.445

High

1281987

DREB
Drebrin

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025