HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	34933446, 29991511, 17041588
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 446
+	Hs
		1202778 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (243-445): 6.45e-42: 155: 17.00
+	Hs
		903171 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (348-445): 9.02e-15: 76.9: 16.33
+	Hs
		903313 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (208-445): 1.16e-53: 186: 15.97
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (248-445): 1.19e-46: 166: 21.21
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (243-445): 6.45e-42: 155: 17.00
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (243-445): 5.09e-42: 155: 17.00
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		793026 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		KTNB1_HUMAN (55-289): 7.58e-23: 103: 15.98
+	Ce
		954090 LIS1_CAEEL (2-289): 8.81e-87: 268: 24.68		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33
+	Hs
		245633 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		TBL1R_HUMAN (94-292): 5.97e-27: 115: 14.08
+	Hs
		1162302 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23
+	Hs
		245613 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23