Protein: CDK8
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (DmCdk8) (Mediator complex subunit Cdk8) (Mediator of RNA polymerase II transcription subunit Cdk8)

Gene: CDK8
Organism: Drosophila melanogaster
Interactions: 67
UniProt ID: Q9VT57

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1269632

MED13
Mediator of RNA polymerase II transcription subunit 13

4

7

Small-scale

0.875

High

668180

CCNC
Cyclin-C

3

20

Small-scale

0.873

High

1485605

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

3

9

Small-scale

0.853

High

1321576

MED6
Mediator of RNA polymerase II transcription subunit 6

2

4

High-throughput

0.737

High

1485966

MED14
Mediator of RNA polymerase II transcription subunit 14

2

9

High-throughput

0.737

High

1485962

MED12
Mediator of RNA polymerase II transcription subunit 12

3

11

Small-scale

0.643

High

889903

DOA
Serine/threonine-protein kinase Doa

1

16

Small-scale

0.618

High

451912

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

0

Small-scale

0.586

High

84987

B7Z126
non-specific serine/threonine protein kinase

1

18

High-throughput

0.575

High

1306299

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.575

High

1343915

Q8SXP8
TAR DNA-binding protein 43

1

10

High-throughput

0.575

High

58511

MED8
Mediator of RNA polymerase II transcription subunit 8

2

3

High-throughput

0.571

High

674057

BRM
ATP-dependent helicase brm

2

4

High-throughput

0.571

High

900672

DSH
Segment polarity protein dishevelled

2

3

High-throughput

0.571

High

1019300

MED20
Mediator of RNA polymerase II transcription subunit 20

2

3

High-throughput

0.571

High

1267070

MED29
Mediator of RNA polymerase II transcription subunit 29

2

3

High-throughput

0.571

High

1303629

OSA
Trithorax group protein osa

2

1

High-throughput

0.571

High

1377798

EBI
F-box-like/WD repeat-containing protein ebi

2

11

High-throughput

0.571

High

1428108

MED7
Mediator of RNA polymerase II transcription subunit 7

2

5

High-throughput

0.571

High

1472586

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

2

3

High-throughput

0.571

High

1472612

MED17
Mediator of RNA polymerase II transcription subunit 17

2

4

High-throughput

0.571

High

1473443

Q9VF03
Brahma associated protein 155 kDa

2

5

High-throughput

0.571

High

1482738

MED27
Mediator of RNA polymerase II transcription subunit 27

2

3

High-throughput

0.571

High

1485337

MED4
Mediator of RNA polymerase II transcription subunit 4

2

3

High-throughput

0.571

High

1485961

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.571

High

1485963

BAP60
Brahma-associated protein of 60 kDa

2

1

High-throughput

0.571

High

1485965

MED30
Mediator of RNA polymerase II transcription subunit 30

2

3

High-throughput

0.571

High

1485968

MED23
Mediator of RNA polymerase II transcription subunit 23

2

3

High-throughput

0.571

High

1485969

MED16
Mediator of RNA polymerase II transcription subunit 16

2

3

High-throughput

0.571

High

1485971

MED18
Mediator of RNA polymerase II transcription subunit 18

2

3

High-throughput

0.571

High

1485972

MED15
Mediator of RNA polymerase II transcription subunit 15

2

9

High-throughput

0.571

High

756505

ECR
Ecdysone receptor

1

17

Small-scale

0.552

High

837181

MAD
Protein mothers against dpp

1

7

Small-scale

0.552

High

1480269

Q9VL29
GEO11246p1

2

0

High-throughput

0.547

High

1321521

ENC
Protein encore

2

2

High-throughput

0.521

High

1378940

Q960F7
SD03629p

2

10

High-throughput

0.521

High

1485959

Q9VUB7
PAX-interacting protein 1

2

17

High-throughput

0.521

High

1485964

Q9W0L7
ubiquitinyl hydrolase 1

2

7

High-throughput

0.521

High

1176457

E2F1
Transcription factor E2f1

1

14

Small-scale

0.515

High

57002

A1ZAK9
P-element somatic inhibitor, isoform A

1

12

Small-scale

0.479

High

583405

DORS
Embryonic polarity protein dorsal

1

5

Small-scale

0.479

High

616646

ARM
Armadillo segment polarity protein

1

13

Small-scale

0.479

High

628543

USP
Protein ultraspiracle

1

12

Small-scale

0.479

High

653093

HSF
Heat shock factor protein

1

7

Small-scale

0.479

High

1022362

DIF
Dorsal-related immunity factor Dif

1

5

Small-scale

0.479

High

1483012

MED1
Mediator of RNA polymerase II transcription subunit 1

1

3

Small-scale

0.479

High

1484618

Q9VR42
Serine/threonine-protein kinase RIO3

1

6

High-throughput

0.479

High

1378328

INT9
Integrator complex subunit 9

1

0

Small-scale

0.458

High

1469071

INT12
Integrator complex subunit 12

1

0

Small-scale

0.458

High

1485967

INT1
Integrator complex subunit 1

1

0

Small-scale

0.458

High

56958

A1ZAK7
LD35640p

1

13

High-throughput

0.445

High

1069938

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

6

High-throughput

0.445

High

1171918

Q24090
GH08712p

1

2

High-throughput

0.445

High

1302896

MED31
Mediator of RNA polymerase II transcription subunit 31

1

5

High-throughput

0.445

High

1409398

Q9BIW6
Brahma-associated protein 111kD

1

4

High-throughput

0.445

High

1427999

MED10
Mediator of RNA polymerase II transcription subunit 10

1

4

High-throughput

0.445

High

1471838

MED25
Mediator of RNA polymerase II transcription subunit 25

1

6

High-throughput

0.445

High

1485571

MED24
Mediator of RNA polymerase II transcription subunit 24

1

3

High-throughput

0.445

High

1485960

MED19
Mediator of RNA polymerase II transcription subunit 19

1

3

High-throughput

0.445

High

1485970

Q9W3G1
Uncharacterized protein, isoform A

1

2

High-throughput

0.445

High

197484

O18353
CHIP

1

0

High-throughput

0.426

High

1345938

Q8T4A8
AT07769p

1

1

High-throughput

0.407

High

1440699

LAR4
La-related protein Larp4B

1

7

High-throughput

0.407

High

402288

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

High-throughput

0.381

High

1261427

Q7JQT8
LD41464p

2

0

High-throughput

0.298

High

1346443

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

84727

UNR
RNA-binding protein Unr

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025