HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1192
+	Hs
		909674 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		WWC2_HUMAN (1-1192): 0: 1008: 100.00
+	Hs
		909790 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		904830 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		904684 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MAGI3_HUMAN (9-97): 1.18e-34: 146: 43.82
+	Hs
		904987 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ITCH_HUMAN (7-143): 1.17e-33: 142: 24.66
+	Hs
		125318 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		910022 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Mm
		808343 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		NEDD4_MOUSE (54-164): 5.95e-20: 98.5: 19.30
+	Mm
		910341 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		RIMS2_MOUSE (556-832): 3.94e-13: 76.6: 13.78
+	Hs
		808077 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Rn
		910358 1433E_RAT (1-244): 2.02e-141: 398: 63.53		NEDD4_RAT (1-241): 4.08e-10: 66.5: 15.32
+	Hs
		808076 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		808460 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		909930 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Mm
		910302 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		NED4L_MOUSE (1-141): 7.95e-09: 62.3: 17.01
+	Mm
		93264 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		E9PXB7_MOUSE (1-141): 7.04e-09: 62.3: 17.01
+	Rn
		905367 1433G_RAT (1-247): 3.15e-139: 392: 100.00		NEDD4_RAT (1-241): 4.08e-10: 66.5: 15.32
+	Hs
		808452 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		905007 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Mm
		93263 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		E9PXB7_MOUSE (1-141): 7.04e-09: 62.3: 17.01