Protein: SYNE1
Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)

Gene: SYNE1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q8NF91

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0003779 - actin binding
GO:0005521 - lamin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338586

SUN2
SUN domain-containing protein 2

3

12

Small-scale

0.892

High

321009

SUN1
SUN domain-containing protein 1

2

12

Small-scale

0.831

High

1338556

SYNE1
Nesprin-1

1

18

Small-scale

0.740

High

179622

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

14

Small-scale

0.713

High

249170

DSCAM
Cell adhesion molecule DSCAM

1

6

High-throughput

0.698

High

909967

MYOM1
Myomesin-1

1

7

High-throughput

0.698

High

165717

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

11

High-throughput

0.691

High

894913

EMD
Emerin

3

4

Small-scale

0.675

High

1338585

IFT57
Intraflagellar transport protein 57 homolog

3

0

High-throughput

0.638

High

385991

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

15

Small-scale

0.624

High

412282

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

1049173

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.618

High

1254717

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

1338582

DISC1
Disrupted in schizophrenia 1 protein

3

9

Small-scale

0.609

High

1155554

EZH2
Histone-lysine N-methyltransferase EZH2

2

6

High-throughput

0.601

High

239425

3BP5
SH3 domain-binding protein 5

2

3

High-throughput

0.576

High

1338567

CEP63
Centrosomal protein of 63 kDa

2

20

High-throughput

0.576

High

1338571

CDC5L
Cell division cycle 5-like protein

2

8

High-throughput

0.576

High

1338588

TNIK
TRAF2 and NCK-interacting protein kinase

2

20

High-throughput

0.576

High

1338560

SYNE2
Nesprin-2

1

17

Small-scale

0.575

High

396550

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

765723

BMI1
Polycomb complex protein BMI-1

2

17

High-throughput

0.571

High

640230

EPHA1
Ephrin type-A receptor 1

1

10

High-throughput

0.553

High

340185

PCNT
Pericentrin

1

20

High-throughput

0.541

High

668667

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.541

High

955390

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.541

High

1154133

ITSN1
Intersectin-1

1

15

High-throughput

0.541

High

1338569

PRPK
EKC/KEOPS complex subunit TP53RK

1

10

High-throughput

0.541

High

1100907

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

1115830

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.536

High

1338577

NDEL1
Nuclear distribution protein nudE-like 1

2

20

High-throughput

0.526

High

1123520

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

426540

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

595524

H15
Histone H1.5

1

3

High-throughput

0.515

High

1211825

AXDN1
Axonemal dynein light chain domain-containing protein 1

1

1

High-throughput

0.515

High

1022751

XIAP
E3 ubiquitin-protein ligase XIAP

1

5

High-throughput

0.501

High

1338562

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.501

High

719508

BKRB2
B2 bradykinin receptor

1

4

High-throughput

0.494

High

1338575

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.493

High

706229

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

1219303

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

Small-scale

0.481

High

1338565

DTBP1
Dysbindin

1

5

High-throughput

0.481

High

1338587

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

Small-scale

0.481

High

157633

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.479

High

159756

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

11

High-throughput

0.479

High

223189

PRC1
Protein regulator of cytokinesis 1

1

17

High-throughput

0.479

High

272328

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

318827

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.479

High

331160

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

346089

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

406408

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

418285

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

4

High-throughput

0.479

High

566764

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

847610

SSRA
Translocon-associated protein subunit alpha

1

3

High-throughput

0.479

High

861225

MAP1B
Microtubule-associated protein 1B

1

14

High-throughput

0.479

High

888198

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

899138

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.479

High

904943

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

945047

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

945278

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.479

High

951279

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

958574

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

3

Small-scale

0.479

High

970803

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

998566

H31
Histone H3.1

1

7

High-throughput

0.479

High

1087198

STX4
Syntaxin-4

1

9

High-throughput

0.479

High

1107033

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1113745

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1127018

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1137109

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

1137401

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1137866

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1141794

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

1149136

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.479

High

1149939

TERF2
Telomeric repeat-binding factor 2

1

10

High-throughput

0.479

High

1161555

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1216681

CROCC
Rootletin

1

20

Small-scale

0.479

High

1312192

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.479

High

1333906

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1338559

NUDC2
NudC domain-containing protein 2

1

5

High-throughput

0.479

High

1338564

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.479

High

1338566

DNJC1
DnaJ homolog subfamily C member 1

1

12

High-throughput

0.479

High

1338570

SEC62
Translocation protein SEC62

1

3

High-throughput

0.479

High

1338572

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1338574

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1338576

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

1338579

GAN
Gigaxonin

1

9

High-throughput

0.479

High

1338580

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.479

High

1338581

ANLN
Anillin

1

9

High-throughput

0.479

High

1338593

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1338595

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

3

Small-scale

0.479

High

1338596

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

443084

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

1013161

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

1094377

CSN1
COP9 signalosome complex subunit 1

1

0

High-throughput

0.458

High

1338557

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1338563

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.458

High

1338568

MUS81
Structure-specific endonuclease subunit MUS81

1

0

High-throughput

0.458

High

1338584

PANK4
4'-phosphopantetheine phosphatase

1

0

High-throughput

0.458

High

1338594

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.458

High

1338558

MIPT3
TRAF3-interacting protein 1

1

6

High-throughput

0.457

High

1338583

EXOC1
Exocyst complex component 1

1

4

High-throughput

0.457

High

255130

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

372621

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.445

High

1007403

S35A1
CMP-sialic acid transporter

1

1

High-throughput

0.445

High

1325994

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

1338561

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

1338589

AGO2
Protein argonaute-2

1

5

High-throughput

0.445

High

1338590

AGO1
Protein argonaute-1

1

5

High-throughput

0.445

High

136940

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

12

High-throughput

0.437

High

353456

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

451415

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.437

High

630894

RAB4A
Ras-related protein Rab-4A

1

11

High-throughput

0.437

High

1111613

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.437

High

1120930

TRI29
Tripartite motif-containing protein 29

1

5

High-throughput

0.437

High

1322900

CXD3
Gap junction delta-3 protein

1

12

High-throughput

0.437

High

1338578

DJC25
DnaJ homolog subfamily C member 25

1

7

High-throughput

0.437

High

479307

P3
P3 protein

1

0

High-throughput

0.426

High

1338591

S45A2
Membrane-associated transporter protein

1

0

High-throughput

0.426

High

947021

DSCR9
Down syndrome critical region protein 9

1

3

High-throughput

0.417

High

1338573

MMP19
Matrix metalloproteinase-19

1

0

High-throughput

0.279

Low

1338592

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

1167080

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025