HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: M3K15 (Q6ZN16)
Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)
Gene: MAP3K15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 1313
+	Hs
		909955 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K5_HUMAN (2-1304): 0: 1235: 55.59
+	Hs
		312790 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K6_HUMAN (22-1301): 0: 1170: 43.52
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (598-1298): 1.18e-137: 440: 14.17
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (598-1298): 7.27e-139: 443: 13.95
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (598-1298): 5.54e-137: 438: 13.90
+	Hs
		909524 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ROCK1_HUMAN (581-1310): 1.12e-126: 426: 18.26
+	Dm
		90534 1433E_DROME (1-254): 2.95e-146: 411: 82.69		E1JGN0_DROME (524-1298): 1.33e-132: 438: 12.95
+	Hs
		909590 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KS6A2_HUMAN (640-1154): 2.44e-123: 401: 19.25
+	At
		788620 14333_ARATH (1-253): 3.45e-147: 413: 74.12		M3K2_ARATH (589-1230): 2.85e-122: 395: 23.94
+	Hs
		681770 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKT1_HUMAN (614-975): 4.08e-116: 373: 19.95
+	Hs
		909502 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK4_HUMAN (656-1080): 1.28e-100: 331: 25.84
+	Hs
		909512 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK3_HUMAN (656-1041): 7.76e-100: 329: 26.21
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (652-969): 8.18e-101: 332: 25.62
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (652-969): 8.18e-101: 332: 25.62
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (652-969): 8.18e-101: 332: 25.62
+	Hs
		909957 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K3_HUMAN (657-907): 3.89e-44: 172: 40.84
+	Hs
		909513 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K1_HUMAN (658-909): 2.79e-42: 171: 36.84
+	Hs
		910191 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K2_HUMAN (657-908): 4.29e-43: 169: 40.68
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (433-657): 6.73e-11: 69.1: 9.96
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (433-650): 1.61e-09: 64.4: 9.82