HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.820

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0000165 - MAPK cascade GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 800
+	At
		965327 14332_ARATH (4-255): 1.05e-147: 414: 74.41		PBS1_ARATH (2-359): 2.99e-132: 403: 19.07
+	Hs
		909438 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		909462 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	At
		965320 14332_ARATH (4-255): 1.05e-147: 414: 74.41		BAK1_ARATH (1-262): 4.62e-126: 392: 21.84
+	At
		1277300 14337_ARATH (2-255): 7.73e-147: 412: 71.21		SERK1_ARATH (1-305): 6.82e-126: 392: 19.94
+	Hs
		909655 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	Hs
		789053 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337416 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85