HitPredict

Interactor 1: SMD3 (P62318)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SNRPD3

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	28977470, 11756452, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0034709 - methylosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 342
+	Hs
		1309327 LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	Hs
		912368 SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	Hs
		1281669 LSM10_HUMAN (7-103): 1.22e-29: 105: 19.59		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	Hs
		911945 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	Hs
		912695 SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		912348 SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		903093 SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903646 LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903091 SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		196993 SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		903627 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Sc
		767803 LSM4_YEAST (5-81): 4.74e-22: 87.8: 26.14		COPA_YEAST (131-323): 1.27e-23: 104: 16.81
+	Hs
		903090 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		197113 LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		197110 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		196988 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40