HitPredict

Interactor 1: PRS10 (P62333)
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
Gene: PSMC6

Interactor 2: ECM29 (Q5VYK3)
Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog)
Gene: ECPAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 20682791
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0036503 - ERAD pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 389 Hs			1 1845
+	Hs
		906856 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		907063 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		798694 PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		730285 PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Sc
		753427 PRS10_YEAST (3-389): 2.22e-122: 362: 67.70		ECM29_YEAST (4-1740): 0: 678: 22.25
+	Sc
		753435 PRS8_YEAST (10-387): 8.63e-117: 347: 43.92		ECM29_YEAST (4-1740): 0: 678: 22.25
+	Sc
		703893 PRS7_YEAST (68-386): 2.09e-103: 315: 48.75		ECM29_YEAST (4-1740): 0: 678: 22.25
+	Rn
		907220 PRS8_RAT (5-387): 7.73e-122: 360: 47.00		CAND1_RAT (282-1301): 1.86e-34: 146: 12.77
+	Rn
		956841 PRS7_RAT (20-377): 9.49e-104: 315: 44.65		CAND1_RAT (282-1301): 1.86e-34: 146: 12.77
+	Sc
		561052 PRS8_YEAST (10-387): 8.63e-117: 347: 43.92		EF3A_YEAST (1093-1349): 9.8e-14: 79.2: 17.11