HitPredict

Interactor 1: PRS10 (P62333)
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
Gene: PSMC6

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30442662, 33277362, 27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0036503 - ERAD pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 389 Hs			1 624
+	Hs
		906941 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		913367 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		906946 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Dm
		1375073 Q9W414_DROME (5-389): 1.73e-131: 384: 89.35		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		913358 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		906929 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Dm
		186163 PRS8_DROME (5-387): 4.86e-126: 370: 47.00		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Xl
		804064 PRS8_XENLA (5-387): 8.3e-124: 367: 46.74		BAG6A_XENLA (28-578): 4.07e-61: 222: 15.47
+	Hs
		913323 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		906885 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		913291 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		906853 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Dm
		186166 PRS8_DROME (5-387): 4.86e-126: 370: 47.00		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		907106 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		907059 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		913240 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		906808 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		913239 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Hs
		906983 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		906982 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27