HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: SCIN (Q9Y6U3)
Scinderin (Adseverin)
Gene: SCIN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 715
+	Hs
		1122544 ACTBL_HUMAN (4-377): 0: 712: 87.97		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		413941 ACTBL_HUMAN (4-377): 0: 712: 87.97		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		892149 ACTB_HUMAN (4-377): 0: 598: 94.12		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		930076 ACTG_HUMAN (4-377): 0: 598: 94.39		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		932481 ACTC_HUMAN (1-377): 0: 598: 98.41		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		933081 ACTS_HUMAN (1-377): 0: 598: 97.88		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		413874 ACTB_HUMAN (4-377): 0: 598: 94.12		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413884 ACTG_HUMAN (4-377): 0: 598: 94.39		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413885 ACTC_HUMAN (1-377): 0: 598: 98.41		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413886 ACTS_HUMAN (1-377): 0: 598: 97.88		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413881 ACTA_HUMAN (1-377): 0: 596: 100.00		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Oc
		101997 ACTB_RABIT (4-377): 0: 595: 93.85		G1U9R8_RABIT (2-715): 0: 1029: 59.86
+	Hs
		891735 ACTB_HUMAN (4-377): 0: 598: 94.12		FLII_HUMAN (6-713): 0: 741: 27.38
+	Hs
		929839 ACTG_HUMAN (4-377): 0: 598: 94.39		FLII_HUMAN (6-713): 0: 741: 27.38
+	Hs
		932132 ACTC_HUMAN (1-377): 0: 598: 98.41		FLII_HUMAN (6-713): 0: 741: 27.38
+	Dm
		950116 ACT6_DROME (1-377): 0: 593: 92.84		FLII_DROME (6-714): 0: 716: 27.89
+	Dm
		501491 ACT1_DROME (1-377): 0: 597: 93.90		QUAI_DROME (7-714): 0: 624: 23.26
+	Bt
		221227 ACTB_BOVIN (4-377): 0: 598: 94.12		SVIL_BOVIN (21-347): 2.8e-32: 137: 21.47
+	Hs
		313786 ACTB_HUMAN (4-377): 0: 598: 94.12		SVIL_HUMAN (21-347): 1.62e-31: 134: 21.73