Protein: NKX21
Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)

Gene: NKX21, NKX2-1
Organism: Homo sapiens
Interactions: 174
UniProt ID: P43699

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

851732

FOXA1
Hepatocyte nuclear factor 3-alpha

3

20

Small-scale

0.669

High

851796

CBP
CREB-binding protein

3

20

Small-scale

0.650

High

851771

NCOA1
Nuclear receptor coactivator 1

2

16

Small-scale

0.619

High

478663

HXB5
Homeobox protein Hox-B5

1

20

Small-scale

0.618

High

851719

NKX21
Homeobox protein Nkx-2.1

1

17

High-throughput

0.618

High

851772

ZFHX3
Zinc finger homeobox protein 3

1

18

High-throughput

0.618

High

851822

SATB2
DNA-binding protein SATB2

1

14

High-throughput

0.618

High

851829

NCOA3
Nuclear receptor coactivator 3

2

20

Small-scale

0.594

High

851752

PAX8
Paired box protein Pax-8

1

18

Small-scale

0.561

High

851814

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

Small-scale

0.506

High

697795

CALR
Calreticulin

1

0

Small-scale

0.504

High

520529

RARA
Retinoic acid receptor alpha

1

15

Small-scale

0.481

High

851770

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.481

High

851812

HIPK2
Homeodomain-interacting protein kinase 2

1

6

Small-scale

0.481

High

851777

CAVN1
Caveolae-associated protein 1

1

0

Small-scale

0.480

High

142496

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.479

High

160165

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

17

High-throughput

0.479

High

243569

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

246464

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

277594

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.479

High

284085

SRS10
Serine/arginine-rich splicing factor 10

1

2

High-throughput

0.479

High

316776

MTA2
Metastasis-associated protein MTA2

1

18

High-throughput

0.479

High

362201

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.479

High

385064

K1C14
Keratin, type I cytoskeletal 14

1

2

High-throughput

0.479

High

385533

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

440434

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.479

High

473847

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487058

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

541880

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.479

High

552525

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

557164

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

High-throughput

0.479

High

557925

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

559255

XRCC5
X-ray repair cross-complementing protein 5

1

7

High-throughput

0.479

High

583490

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

12

High-throughput

0.479

High

584003

FOSL1
Fos-related antigen 1

1

14

High-throughput

0.479

High

588127

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

593939

NCK1
SH2/SH3 adapter protein NCK1

1

13

High-throughput

0.479

High

603623

JUNB
Transcription factor JunB

1

14

High-throughput

0.479

High

605242

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

13

High-throughput

0.479

High

606383

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

610258

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

617662

XRCC1
DNA repair protein XRCC1

1

1

High-throughput

0.479

High

634339

LMNB1
Lamin-B1

1

3

High-throughput

0.479

High

655102

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

High-throughput

0.479

High

687347

PTBP1
Polypyrimidine tract-binding protein 1

1

3

High-throughput

0.479

High

694847

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

703106

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

756116

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

766283

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

767622

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

769672

RFC4
Replication factor C subunit 4

1

4

High-throughput

0.479

High

769823

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.479

High

769938

RFC1
Replication factor C subunit 1

1

6

High-throughput

0.479

High

771966

K1C9
Keratin, type I cytoskeletal 9

1

3

High-throughput

0.479

High

774903

FUS
RNA-binding protein FUS

1

5

High-throughput

0.479

High

789072

NUP62
Nuclear pore glycoprotein p62

1

2

High-throughput

0.479

High

794400

RBMX
RNA-binding motif protein, X chromosome

1

3

High-throughput

0.479

High

829045

RFC5
Replication factor C subunit 5

1

4

High-throughput

0.479

High

829182

RFC3
Replication factor C subunit 3

1

4

High-throughput

0.479

High

832957

ETV6
Transcription factor ETV6

1

20

High-throughput

0.479

High

837432

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

851720

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.479

High

851721

CRK
Adapter molecule crk

1

8

High-throughput

0.479

High

851723

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

851724

DNLI3
DNA ligase 3

1

3

High-throughput

0.479

High

851725

DNLI4
DNA ligase 4

1

3

High-throughput

0.479

High

851726

EMD
Emerin

1

4

High-throughput

0.479

High

851727

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

851728

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

3

High-throughput

0.479

High

851729

NUP98
Nuclear pore complex protein Nup98-Nup96

1

10

High-throughput

0.479

High

851730

XPO2
Exportin-2

1

2

High-throughput

0.479

High

851733

SEC13
Protein SEC13 homolog

1

6

High-throughput

0.479

High

851735

H4
Histone H4

1

3

High-throughput

0.479

High

851736

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

851737

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

851738

TRA2B
Transformer-2 protein homolog beta

1

3

High-throughput

0.479

High

851740

H31
Histone H3.1

1

3

High-throughput

0.479

High

851742

RAE1L
mRNA export factor RAE1

1

12

High-throughput

0.479

High

851743

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

851745

H33
Histone H3.3

1

3

High-throughput

0.479

High

851746

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.479

High

851748

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

851749

TF65
Transcription factor p65

1

6

Small-scale

0.479

High

851750

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

6

High-throughput

0.479

High

851751

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.479

High

851753

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.479

High

851754

RBBP4
Histone-binding protein RBBP4

1

8

High-throughput

0.479

High

851756

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.479

High

851757

ILF2
Interleukin enhancer-binding factor 2

1

2

High-throughput

0.479

High

851758

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

851759

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

851761

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

7

High-throughput

0.479

High

851762

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

851764

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

8

High-throughput

0.479

High

851765

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

High-throughput

0.479

High

851767

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

15

High-throughput

0.479

High

851768

IMB1
Importin subunit beta-1

1

1

High-throughput

0.479

High

851769

NONO
Non-POU domain-containing octamer-binding protein

1

8

High-throughput

0.479

High

851773

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

851774

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

851778

H2AV
Histone H2A.V

1

2

High-throughput

0.479

High

851779

APTX
Aprataxin

1

3

High-throughput

0.479

High

851780

I2BP2
Interferon regulatory factor 2-binding protein 2

1

17

High-throughput

0.479

High

851781

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

851782

I2BP1
Interferon regulatory factor 2-binding protein 1

1

5

High-throughput

0.479

High

851783

VRK3
Serine/threonine-protein kinase VRK3

1

2

High-throughput

0.479

High

851785

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

851788

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.479

High

851789

NUP37
Nucleoporin Nup37

1

12

High-throughput

0.479

High

851790

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

851792

ZN384
Zinc finger protein 384

1

5

High-throughput

0.479

High

851794

JDP2
Jun dimerization protein 2

1

12

High-throughput

0.479

High

851797

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.479

High

851800

RBM14
RNA-binding protein 14

1

3

High-throughput

0.479

High

851802

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

2

High-throughput

0.479

High

851804

OVOL2
Transcription factor Ovo-like 2

1

5

High-throughput

0.479

High

851806

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

5

High-throughput

0.479

High

851809

PDIP3
Polymerase delta-interacting protein 3

1

6

High-throughput

0.479

High

851810

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

12

High-throughput

0.479

High

851811

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

20

High-throughput

0.479

High

851813

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

851815

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

18

High-throughput

0.479

High

851816

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.479

High

851817

PARP2
Poly [ADP-ribose] polymerase 2

1

6

High-throughput

0.479

High

851818

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

851819

PUF60
Poly(U)-binding-splicing factor PUF60

1

4

High-throughput

0.479

High

851820

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

851821

MAFF
Transcription factor MafF

1

5

High-throughput

0.479

High

851823

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

851824

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

851825

FOXA2
Hepatocyte nuclear factor 3-beta

1

20

Small-scale

0.479

High

851826

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

851827

AMOL2
Angiomotin-like protein 2

1

3

High-throughput

0.479

High

851828

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.479

High

228200

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

285608

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

407409

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.458

High

408719

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

542373

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

550911

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

601587

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

616264

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.458

High

851722

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

851731

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

851739

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

851760

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.458

High

851763

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

851766

MVP
Major vault protein

1

0

High-throughput

0.458

High

851786

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

851787

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.458

High

851803

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

851808

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.458

High

851744

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.457

High

821247

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.437

High

851741

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.437

High

851795

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

851798

SEH1
Nucleoporin SEH1

1

6

High-throughput

0.437

High

851799

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

2

High-throughput

0.437

High

851807

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.437

High

48552

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.249

Low

291246

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

359611

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

618660

ML12A
Myosin regulatory light chain 12A

1

0

High-throughput

0.249

Low

851734

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.249

Low

851747

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.249

Low

851755

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

851775

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

851776

TM214
Transmembrane protein 214

1

0

High-throughput

0.249

Low

851784

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.249

Low

851791

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

851793

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.249

Low

851801

TM209
Transmembrane protein 209

1

0

High-throughput

0.249

Low

851805

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025