HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	33961781, 8598932, 14578449, 22467210
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 129
+	Hs
		917544 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		917757 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06
+	Hs
		917817 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06
+	Hs
		470324 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		917438 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		917496 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28
+	Hs
		917699 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1C_HUMAN (1-127): 4.25e-65: 195: 96.06
+	Hs
		391638 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		594838 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1D_HUMAN (1-127): 6.03e-65: 194: 95.28
+	Hs
		555395 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Dm
		950379 H4_DROME (1-103): 4.51e-48: 150: 99.03		H2A_DROME (17-122): 5.55e-57: 174: 92.45
+	Sc
		356147 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2A1_YEAST (16-129): 1.56e-52: 163: 78.95
+	Sc
		356148 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2A2_YEAST (16-129): 1.63e-52: 163: 78.95