Protein: RPN6
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)

Gene: RPN6
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: Q12377

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005198 - structural molecule activity
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084670

RPN5
26S proteasome regulatory subunit RPN5

21

19

Small-scale

0.988

High

1064742

RPN8
26S proteasome regulatory subunit RPN8

11

20

Small-scale

0.976

High

1044981

RPN9
26S proteasome regulatory subunit RPN9

11

20

Small-scale

0.976

High

1053600

RPN7
26S proteasome regulatory subunit RPN7

11

18

Small-scale

0.975

High

817103

RPN3
26S proteasome regulatory subunit RPN3

10

16

Small-scale

0.970

High

738348

RPN12
26S proteasome regulatory subunit RPN12

9

3

Small-scale

0.967

High

645218

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.881

High

661575

PSA2
Proteasome subunit alpha type-2

4

20

Small-scale

0.878

High

314916

SEM1
26S proteasome complex subunit SEM1

5

0

Small-scale

0.865

High

822030

PSA4
Proteasome subunit alpha type-4

2

20

High-throughput

0.789

High

1084837

RPN6
26S proteasome regulatory subunit RPN6

2

18

High-throughput

0.776

High

850273

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

30

20

Small-scale

0.768

High

636619

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.754

High

636698

PSA1
Proteasome subunit alpha type-1

2

20

High-throughput

0.754

High

661449

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.754

High

803723

RPN1
26S proteasome regulatory subunit RPN1

9

15

Small-scale

0.748

High

806841

RPN10
26S proteasome regulatory subunit RPN10

8

4

Small-scale

0.748

High

751022

PRS7
26S proteasome regulatory subunit 7 homolog

8

20

Small-scale

0.747

High

750911

PRS6B
26S proteasome regulatory subunit 6B homolog

7

20

Small-scale

0.746

High

1033909

PRS8
26S proteasome regulatory subunit 8 homolog

6

20

High-throughput

0.732

High

750805

PRS6A
26S proteasome regulatory subunit 6A

6

20

Small-scale

0.730

High

921117

PRS10
26S proteasome subunit RPT4

5

20

High-throughput

0.714

High

740238

RPN2
26S proteasome regulatory subunit RPN2

5

14

Small-scale

0.709

High

822447

PRS4
26S proteasome regulatory subunit 4 homolog

4

20

High-throughput

0.694

High

850361

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

3

High-throughput

0.694

High

803183

ECM29
Proteasome component ECM29

4

2

High-throughput

0.691

High

744029

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.683

High

918110

RPN14
26S proteasome regulatory subunit RPN14

3

4

High-throughput

0.667

High

150316

RPN13
26S proteasome regulatory subunit RPN13

4

0

High-throughput

0.664

High

893081

PSD10
Probable 26S proteasome regulatory subunit p28

4

3

Small-scale

0.630

High

525606

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.624

High

668421

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

675270

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

721335

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

735970

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

800869

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

821997

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

580274

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

528065

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

826326

PSMD9
Probable 26S proteasome regulatory subunit p27

2

3

Small-scale

0.533

High

1046212

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.529

High

546813

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.504

High

574757

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.489

High

811609

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.489

High

1027302

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.489

High

393548

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

680178

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

924469

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

4

High-throughput

0.479

High

1042277

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

726059

FUN30
ATP-dependent helicase FUN30

1

1

High-throughput

0.470

High

734497

BTAF1
TATA-binding protein-associated factor MOT1

1

1

High-throughput

0.470

High

807882

VPS45
Vacuolar protein sorting-associated protein 45

1

2

High-throughput

0.470

High

776678

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

509768

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

17

High-throughput

0.457

High

557651

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

3

Small-scale

0.437

High

616466

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

753657

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

779381

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

925153

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

1084305

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.437

High

1084380

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.437

High

1084838

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

554070

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.407

High

727416

HS104
Heat shock protein 104

1

1

High-throughput

0.407

High

752904

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

798080

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

17

High-throughput

0.407

High

820168

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

826515

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.407

High

1056461

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.407

High

798581

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.369

High

1044851

SCC2
Sister chromatid cohesion protein 2

2

0

High-throughput

0.313

High

365714

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.307

High

671262

SIS1
Protein SIS1

2

0

High-throughput

0.305

High

1043577

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

795948

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.279

Low

798011

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

919649

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.279

Low

733832

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.269

Low

751564

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.269

Low

757419

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.269

Low

781087

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

0

High-throughput

0.269

Low

813933

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.269

Low

395271

GCN4
General control transcription factor GCN4

1

0

High-throughput

0.265

Low

383953

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

435443

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

558905

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

603125

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

647250

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

674898

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

679063

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

708580

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735234

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

738944

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

795605

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

802451

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

818559

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

844667

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

874596

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

877944

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

1033636

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1042834

RPN4
Protein RPN4

1

0

Small-scale

0.249

Low

1046095

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

1054017

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1054876

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1084814

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.249

Low

1084839

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

672623

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.238

Low

671745

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

747644

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

818213

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

863794

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025