HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: H2A3 (Q7L7L0)
Histone H2A type 3 (H2A-clustered histone 25)
Gene: H2AC25

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30804502, 34349018
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 130
+	Hs
		391638 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1B_HUMAN (1-130): 7.3e-68: 202: 99.23
+	Hs
		470324 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1_HUMAN (1-130): 5.87e-68: 202: 97.69
+	Hs
		594838 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1D_HUMAN (1-130): 6.69e-68: 202: 98.46
+	Hs
		917438 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2A_HUMAN (1-130): 4.18e-68: 202: 97.69
+	Hs
		917699 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1C_HUMAN (1-130): 4.66e-68: 202: 99.23
+	Hs
		917817 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1J_HUMAN (1-128): 2.34e-67: 201: 96.88
+	Hs
		917757 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1H_HUMAN (1-128): 3.59e-67: 200: 97.66
+	Hs
		917544 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2B_HUMAN (1-130): 1.66e-66: 199: 94.62
+	Hs
		917354 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2C_HUMAN (1-130): 2.58e-65: 195: 96.15
+	Hs
		555395 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2AX_HUMAN (1-130): 5.7e-64: 192: 88.81
+	Dm
		950379 H4_DROME (1-103): 4.51e-48: 150: 99.03		H2A_DROME (17-125): 5.76e-60: 182: 89.91
+	Sc
		356148 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2A2_YEAST (16-128): 1.62e-59: 181: 80.53
+	Sc
		356147 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2A1_YEAST (16-127): 4.87e-53: 164: 81.25