Protein: PRP4
U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4)

Gene: PRP4
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: P20053

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000393 - spliceosomal conformational changes to generate catalytic conformation
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

627868

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

7

4

Small-scale

0.972

High

627841

BRR2
Pre-mRNA-splicing helicase BRR2

9

19

Small-scale

0.968

High

627842

PRP8
Pre-mRNA-splicing factor 8

4

4

Small-scale

0.892

High

627845

SN114
Pre-mRNA-splicing factor SNU114

3

6

High-throughput

0.855

High

624963

PRP6
Pre-mRNA-splicing factor 6

6

18

Small-scale

0.732

High

627857

LSM8
LSM2-LSM8 complex subunit LSM8

5

15

Small-scale

0.715

High

627883

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

5

4

Small-scale

0.712

High

627863

LSM3
LSM complex subunit LSM3

5

20

Small-scale

0.706

High

627861

LSM7
LSM complex subunit LSM7

4

15

High-throughput

0.697

High

627858

PRP31
Pre-mRNA-processing factor 31

4

8

High-throughput

0.694

High

627850

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

6

High-throughput

0.691

High

627862

RUXF
Small nuclear ribonucleoprotein F

4

6

High-throughput

0.683

High

627838

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

2

10

High-throughput

0.679

High

627828

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

13

High-throughput

0.665

High

627849

SNU13
13 kDa ribonucleoprotein-associated protein

1

10

High-throughput

0.665

High

627847

LSM2
LSM complex subunit LSM2

3

18

High-throughput

0.662

High

627853

RUXG
Small nuclear ribonucleoprotein G

3

11

High-throughput

0.643

High

627881

RUXE
Small nuclear ribonucleoprotein E

3

3

High-throughput

0.643

High

627848

SP381
Pre-mRNA-splicing factor SPP381

3

0

High-throughput

0.634

High

627882

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

0

High-throughput

0.634

High

584339

GCN2
eIF-2-alpha kinase GCN2

2

3

High-throughput

0.621

High

627852

LSM5
LSM complex subunit LSM5

2

2

High-throughput

0.621

High

627870

LSM6
LSM complex subunit LSM6

2

6

High-throughput

0.621

High

627837

ARP2
Actin-related protein 2

1

7

High-throughput

0.618

High

627851

LSM4
LSM complex subunit LSM4

2

8

High-throughput

0.611

High

627869

SMD2
Small nuclear ribonucleoprotein Sm D2

2

3

High-throughput

0.601

High

627867

UTP17
NET1-associated nuclear protein 1

1

13

High-throughput

0.595

High

627871

RRP9
Ribosomal RNA-processing protein 9

1

20

High-throughput

0.595

High

627854

SMD3
Small nuclear ribonucleoprotein Sm D3

2

18

Small-scale

0.584

High

626575

HSP60
Heat shock protein 60, mitochondrial

1

20

High-throughput

0.578

High

419588

H2A2
Histone H2A.2

1

5

High-throughput

0.575

High

523021

HSP71
Heat shock protein SSA1

2

17

Small-scale

0.571

High

627839

PRP19
Pre-mRNA-processing factor 19

2

17

Small-scale

0.571

High

627836

XPO1
Exportin-1

1

11

High-throughput

0.536

High

627840

PRP21
Pre-mRNA-splicing factor PRP21

1

3

High-throughput

0.536

High

627843

LHP1
La protein homolog

1

6

High-throughput

0.515

High

627856

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

5

High-throughput

0.515

High

627865

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.515

High

627877

SAS10
Something about silencing protein 10

1

1

High-throughput

0.515

High

627884

NOP56
Nucleolar protein 56

1

8

High-throughput

0.515

High

392207

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.500

High

590524

HSP26
Heat shock protein 26

1

4

High-throughput

0.500

High

627832

CDC48
Cell division control protein 48

1

7

High-throughput

0.500

High

585584

STI1
Heat shock protein STI1

1

17

High-throughput

0.489

High

439237

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

627834

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

627835

BMH1
Protein BMH1

1

4

High-throughput

0.479

High

627866

SMD1
Small nuclear ribonucleoprotein Sm D1

1

2

High-throughput

0.479

High

627872

DIB1
Spliceosomal protein DIB1

1

2

High-throughput

0.479

High

627874

NCBP2
Nuclear cap-binding protein subunit 2

1

4

High-throughput

0.479

High

627875

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.479

High

627878

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

627879

YRA1
RNA annealing protein YRA1

1

7

High-throughput

0.479

High

585201

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

4

High-throughput

0.470

High

627886

NOP58
Nucleolar protein 58

1

8

High-throughput

0.470

High

627846

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

627864

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

366921

ATPB
ATP synthase subunit beta, mitochondrial

1

6

High-throughput

0.457

High

367689

ENO1
Enolase 1

1

2

High-throughput

0.457

High

405023

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.457

High

575378

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

3

High-throughput

0.457

High

627829

CLH
Clathrin heavy chain

1

6

High-throughput

0.457

High

627830

SCJ1
DnaJ-related protein SCJ1

1

5

High-throughput

0.457

High

627844

MDJ1
DnaJ homolog 1, mitochondrial

1

5

High-throughput

0.457

High

627880

HSP42
Heat shock protein 42

1

6

High-throughput

0.457

High

543777

SSB1
Ribosome-associated molecular chaperone SSB1

1

18

High-throughput

0.445

High

627831

MSH3
DNA mismatch repair protein MSH3

1

1

High-throughput

0.445

High

578821

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.437

High

627876

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

2

High-throughput

0.437

High

627855

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.407

High

627833

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.269

Low

627859

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.269

Low

627873

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.269

Low

627885

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.269

Low

432287

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

627860

FOL1
Folic acid synthesis protein FOL1 [Includes: Dihydroneopterin aldolase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025