HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: Q8NEX1 (Q8NEX1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Gene: Q8NEX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19690564
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 180
+	Hs
		1243628 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		Q8NEX1_HUMAN (1-180): 9.28e-64: 195: 100.00
+	Hs
		1245518 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00
+	Hs
		919793 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ZNRF2_HUMAN (21-180): 1.53e-53: 171: 100.00
+	Hs
		1242076 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46
+	Hs
		919790 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ZNRF1_HUMAN (12-180): 1.49e-45: 151: 49.46
+	Zm
		74334 B4FC97_MAIZE (1-147): 3e-83: 242: 79.59		B6U926_MAIZE (41-180): 2.38e-33: 123: 24.83
+	Zm
		79637 B6SZE0_MAIZE (1-147): 3.82e-83: 242: 79.59		B6U926_MAIZE (41-180): 2.38e-33: 123: 24.83
+	Hs
		1377467 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN115_HUMAN (34-178): 3.78e-32: 118: 17.45
+	Hs
		1204871 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		GOLI_HUMAN (109-180): 1.33e-27: 108: 26.39
+	Hs
		1356934 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN150_HUMAN (109-180): 1.33e-26: 106: 26.39
+	Hs
		919772 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		GOLI_HUMAN (109-180): 1.33e-27: 108: 26.39
+	Hs
		919903 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN150_HUMAN (109-180): 1.33e-26: 106: 26.39
+	Hs
		1313520 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN126_HUMAN (10-178): 1.22e-25: 101: 18.39
+	Hs
		919789 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN149_HUMAN (111-180): 6.82e-26: 103: 32.86
+	Hs
		919840 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN126_HUMAN (10-178): 1.22e-25: 101: 18.39
+	Hs
		1377465 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF11_HUMAN (114-180): 5.25e-22: 88.7: 37.68
+	Hs
		1332598 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN167_HUMAN (118-175): 2.32e-10: 60.1: 37.10
+	Hs
		1170316 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ARK2C_HUMAN (131-175): 2.6e-10: 59.8: 37.78
+	Hs
		919862 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN167_HUMAN (118-175): 2.32e-10: 60.1: 37.10
+	Hs
		919759 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ARK2C_HUMAN (131-175): 2.6e-10: 59.8: 37.78