HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	29643511, 32296183, 19549727, 36074076, 20152160, unassigned1304, 14667819
Identification Methods	pull down, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 180
+	Hs
		1307272 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		1292368 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		919826 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		919822 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI11_HUMAN (14-148): 2.69e-31: 119: 17.78
+	Hs
		919712 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI26_HUMAN (14-123): 1.73e-28: 112: 21.85
+	Hs
		1318532 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		1336390 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919851 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		919870 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919828 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN170_HUMAN (12-133): 1.15e-26: 103: 22.48
+	Hs
		1354526 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		584923 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Mm
		919925 UB2D2_MOUSE (1-147): 9.5e-83: 241: 100.00		TRI17_MOUSE (13-148): 1.18e-24: 100: 13.10
+	Hs
		919892 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		262201 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		262161 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		262167 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		919852 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRIM7_HUMAN (1-101): 4.17e-21: 91.3: 23.48
+	Hs
		919905 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		CBLC_HUMAN (6-93): 1.05e-19: 87.1: 28.28
+	Hs
		749339 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62