HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: 3BP2 (P78314)
SH3 domain-binding protein 2 (3BP-2)
Gene: SH3BP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9846481
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, PH~SH3_1, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0007165 - signal transduction GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 561
+	Hs
		940679 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00
+	Hs
		411669 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00
+	Mm
		337628 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		3BP2_MOUSE (1-561): 3e-105: 329: 86.63
+	Hs
		337423 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00
+	Hs
		548682 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00
+	Hs
		412125 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (147-560): 2.58e-13: 75.2: 10.05
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (69-521): 1.59e-10: 66.4: 9.75
+	Hs
		517796 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NFH_HUMAN (95-479): 5.25e-09: 61.2: 13.04
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (77-547): 1.99e-37: 150: 15.72
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (147-560): 2.58e-13: 75.2: 10.05
+	Hs
		411876 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FMN2_HUMAN (202-477): 8.26e-10: 64.1: 20.50
+	Hs
		433853 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MICA3_HUMAN (161-510): 2.13e-25: 113: 14.77
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (147-560): 2.58e-13: 75.2: 10.05
+	Hs
		203228 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48
+	Hs
		433560 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC1_HUMAN (147-560): 2.58e-13: 75.2: 10.05
+	Hs
		434041 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		FMN2_HUMAN (202-477): 8.26e-10: 64.1: 20.50