HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	32296183, 22365833, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000375 - RNA splicing, via transesterification reactions GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 494
+	Hs
		992758 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		925011 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		1028895 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		1028541 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Mm
		192621 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF5_MOUSE (3-175): 9.86e-54: 183: 64.57
+	Hs
		1029130 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		925021 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		993707 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00
+	Hs
		925020 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Hs
		1028644 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Mm
		925167 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF9_MOUSE (3-216): 4.58e-52: 177: 36.53
+	Hs
		1028634 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Hs
		993869 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00
+	Hs
		1028873 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516744 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		474022 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PAB4L_HUMAN (100-185): 1.44e-10: 65: 19.78
+	Mm
		857303 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		TIA1_MOUSE (98-188): 7.57e-10: 62.7: 17.02