HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: SYDE2 (Q5VT97)
Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)
Gene: SYDE2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1194
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (373-1189): 9.41e-95: 336: 17.25
+	Hs
		925379 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SYDE1_HUMAN (428-1188): 1.17e-98: 332: 36.25
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (397-1174): 2.62e-91: 320: 11.72
+	Hs
		925192 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG04_HUMAN (396-1185): 2.58e-91: 317: 13.17
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (540-1036): 4.57e-91: 303: 17.09
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (519-1038): 1.9e-85: 298: 22.24
+	Hs
		253337 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP2_HUMAN (397-1194): 2.33e-81: 291: 13.95
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (351-1033): 1.43e-81: 288: 15.12
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (533-1038): 2.5e-74: 272: 24.04
+	Hs
		506566 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		BCR_HUMAN (533-1038): 3.93e-72: 265: 23.85
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (702-1194): 1.04e-71: 264: 16.36
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (712-1144): 4.73e-66: 239: 18.30
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (690-1059): 4.21e-61: 228: 20.26
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (804-1031): 5.8e-64: 227: 26.75
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (804-1031): 2.29e-65: 226: 28.51
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (804-1031): 7.05e-63: 223: 28.95
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (783-1026): 1.32e-54: 211: 27.53
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (783-1026): 4.26e-54: 210: 27.53
+	Hs
		925227 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG01_HUMAN (814-998): 2.83e-54: 198: 25.95
+	Mm
		925791 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG01_MOUSE (814-998): 1.73e-53: 195: 25.95