HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: SH3R2 (Q8TEC5)
E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
Gene: SH3RF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22128169
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 729
+	Hs
		925460 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R3_HUMAN (1-729): 6.38e-87: 294: 30.14
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Hs
		545368 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Hs
		925289 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		564535 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		1049733 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Gg
		1141019 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		ARHG6_CHICK (66-673): 1.48e-57: 210: 14.49
+	Hs
		892365 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Hs
		545388 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		893997 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ARHG7_HUMAN (63-661): 5.46e-63: 227: 12.40
+	Hs
		1066050 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		892381 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		894026 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ARHG6_HUMAN (86-677): 9.72e-60: 217: 12.78
+	Hs
		925396 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R1_HUMAN (1-729): 3.75e-52: 196: 26.51
+	Hs
		894097 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		SH319_HUMAN (97-253): 2.17e-22: 104: 26.22
+	Hs
		925374 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DNMBP_HUMAN (76-438): 8.64e-10: 64.6: 11.86
+	Hs
		894047 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ITSN1_HUMAN (221-540): 6.08e-15: 81.2: 9.76
+	Hs
		892443 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		DNMBP_HUMAN (76-438): 8.64e-10: 64.6: 11.86
+	Hs
		951095 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		DNMBP_HUMAN (76-438): 8.64e-10: 64.6: 11.86