HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ECT2 (Q9H8V3)
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Gene: ECT2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32929379
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005938 - cell cortex GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 914
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (309-913): 4.64e-90: 305: 11.83
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (258-880): 7.04e-90: 301: 16.67
+	Hs
		925497 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG2_HUMAN (249-775): 2e-83: 291: 15.02
+	Hs
		156397 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RGRF2_HUMAN (271-867): 6.88e-81: 287: 15.42
+	Hs
		925455 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX1_HUMAN (406-861): 1.32e-78: 282: 18.47
+	Hs
		925727 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG1_HUMAN (367-887): 3.48e-78: 280: 16.79
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (350-880): 1.39e-79: 274: 17.20
+	Hs
		50580 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG3_HUMAN (394-892): 2.49e-76: 273: 18.53
+	Hs
		925382 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX2_HUMAN (437-787): 4.86e-75: 271: 18.68
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (390-707): 1.61e-76: 269: 21.82
+	Hs
		925436 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NGEF_HUMAN (354-827): 7.02e-77: 267: 17.15
+	Hs
		925512 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGQ_HUMAN (338-819): 7.05e-75: 265: 16.92
+	Hs
		925416 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGJ_HUMAN (378-821): 6.57e-75: 264: 18.90
+	Hs
		925718 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV3_HUMAN (382-707): 3.15e-73: 260: 22.58
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (386-707): 7.77e-69: 248: 18.94
+	Hs
		164115 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGA_HUMAN (436-704): 1.71e-23: 109: 29.33
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (453-641): 7.1e-16: 84.7: 28.72
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (463-641): 8.72e-16: 84.3: 30.27
+	Hs
		506566 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		BCR_HUMAN (453-641): 1.17e-14: 80.9: 27.69
+	Hs
		167081 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGB_HUMAN (453-651): 2.54e-12: 73.2: 23.53