HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030027 - lamellipodium GO:0042995 - cell projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 1161
+	Hs
		148653 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		724757 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		254468 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		254445 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		925344 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		564564 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		254512 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		925488 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		545430 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		724776 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		254472 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		564633 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		1137905 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		545537 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		951069 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		925766 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		564758 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		545725 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		1331011 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		725138 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27