Protein: TSYL6
Testis-specific Y-encoded-like protein 6 (TSPY-like protein 6)

Gene: TSYL6, TSPYL6
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q8N831

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006334 - nucleosome assembly
GO:0042393 - histone binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1330833

TSYL2
Testis-specific Y-encoded-like protein 2

4

15

High-throughput

0.900

High

960489

PSME3
Proteasome activator complex subunit 3

4

2

High-throughput

0.697

High

275904

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

3

5

High-throughput

0.662

High

967158

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

3

5

High-throughput

0.662

High

1330813

WDR48
WD repeat-containing protein 48

3

3

High-throughput

0.662

High

1330814

WDR20
WD repeat-containing protein 20

3

4

High-throughput

0.662

High

848413

MAGA6
Melanoma-associated antigen 6

3

8

High-throughput

0.647

High

537522

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

777304

AHR
Aryl hydrocarbon receptor

2

2

High-throughput

0.628

High

1028286

MDM2
E3 ubiquitin-protein ligase Mdm2

2

2

High-throughput

0.628

High

1108613

TBB3
Tubulin beta-3 chain

2

2

High-throughput

0.628

High

1123579

ZMYM3
Zinc finger MYM-type protein 3

2

1

High-throughput

0.628

High

1229566

VIR
Protein virilizer homolog

2

2

High-throughput

0.628

High

1243019

PKN3
Serine/threonine-protein kinase N3

2

5

High-throughput

0.628

High

1246133

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

2

High-throughput

0.628

High

1330825

SMC6
Structural maintenance of chromosomes protein 6

2

4

High-throughput

0.628

High

1330829

RN126
E3 ubiquitin-protein ligase RNF126

2

1

High-throughput

0.628

High

1330840

ZMYM2
Zinc finger MYM-type protein 2

2

1

High-throughput

0.628

High

1330841

KDM5B
Lysine-specific demethylase 5B

2

5

High-throughput

0.628

High

1330843

MCM8
DNA helicase MCM8

2

6

High-throughput

0.628

High

1330831

DDX24
ATP-dependent RNA helicase DDX24

3

5

High-throughput

0.616

High

1330821

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.606

High

1330826

MDFI
MyoD family inhibitor

2

2

High-throughput

0.606

High

451544

CENPB
Major centromere autoantigen B

2

0

High-throughput

0.602

High

926101

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

1330817

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

0

High-throughput

0.602

High

1330838

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

2

0

High-throughput

0.602

High

1330824

MAGD4
Melanoma-associated antigen D4

2

8

High-throughput

0.601

High

1330822

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.580

High

143874

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

2

High-throughput

0.574

High

1191888

TBB8
Tubulin beta-8 chain

2

2

High-throughput

0.574

High

1206615

AMER1
APC membrane recruitment protein 1

2

1

High-throughput

0.574

High

1245312

WDR59
GATOR2 complex protein WDR59

2

4

High-throughput

0.574

High

1325668

GUF1
Translation factor GUF1, mitochondrial

2

1

High-throughput

0.574

High

1330815

DMXL2
DmX-like protein 2

2

2

High-throughput

0.574

High

1330823

TTC28
Tetratricopeptide repeat protein 28

2

6

High-throughput

0.574

High

1330834

TBB1
Tubulin beta-1 chain

2

3

High-throughput

0.574

High

1225009

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

3

High-throughput

0.553

High

408103

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.536

High

1032363

OTUD4
OTU domain-containing protein 4

1

2

High-throughput

0.536

High

1257917

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

9

High-throughput

0.536

High

1259351

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.536

High

1330827

TBA1C
Tubulin alpha-1C chain

1

4

High-throughput

0.536

High

1330842

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

231729

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.489

High

996771

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

1330812

PJA1
E3 ubiquitin-protein ligase Praja-1

1

3

High-throughput

0.489

High

1330819

MADD
MAP kinase-activating death domain protein

1

1

High-throughput

0.489

High

1330820

K0232
Uncharacterized protein KIAA0232

1

1

High-throughput

0.489

High

1330839

RRBP1
Ribosome-binding protein 1

1

2

High-throughput

0.489

High

1330844

SNX6
Sorting nexin-6

1

1

High-throughput

0.445

High

1330832

PIP30
PSME3-interacting protein

1

0

High-throughput

0.426

High

1204536

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

5

High-throughput

0.407

High

1330830

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.407

High

1133216

STAR3
StAR-related lipid transfer protein 3

2

0

High-throughput

0.328

High

1330811

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

2

0

High-throughput

0.328

High

1330835

HEAT1
HEAT repeat-containing protein 1

2

0

High-throughput

0.328

High

1330845

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

2

0

High-throughput

0.328

High

1186665

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1186837

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1186890

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

1198031

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.316

High

1307077

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

67484

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.279

Low

169118

ML12B
Myosin regulatory light chain 12B

1

0

High-throughput

0.279

Low

952605

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.279

Low

1330816

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

1330836

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

1330837

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.279

Low

1186771

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

1220649

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1041454

ACY1
Aminoacylase-1

1

0

High-throughput

0.232

Low

1286977

DAAM2
Disheveled-associated activator of morphogenesis 2

1

0

High-throughput

0.232

Low

1330818

DNJA4
DnaJ homolog subfamily A member 4

1

0

High-throughput

0.232

Low

1330828

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025