HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	36736316, 33961781, 35271311, 14676191, 16306228, 28514442
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 795
+	Mm
		910318 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK1_MOUSE (1-795): 0: 767: 94.34
+	Mm
		910234 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK2_MOUSE (2-795): 0: 672: 64.55
+	Hs
		927214 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		926780 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MARK3_MOUSE (1-795): 0: 662: 62.87
+	Hs
		647862 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		910231 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK3_MOUSE (1-795): 0: 662: 62.87
+	Hs
		927411 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Mm
		910308 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK4_MOUSE (1-795): 0: 569: 49.01
+	Hs
		927047 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MELK_HUMAN (56-795): 1.01e-161: 485: 25.30
+	Mm
		926816 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		SIK3_MOUSE (56-615): 6.82e-141: 451: 38.31
+	Hs
		927511 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK2_HUMAN (45-766): 2.35e-142: 444: 28.27
+	Hs
		927683 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK3_HUMAN (36-620): 8.16e-139: 444: 36.67
+	Hs
		883215 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Hs
		883214 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Rn
		871214 1433E_RAT (2-241): 9.9e-144: 403: 68.18		AAPK1_RAT (34-579): 1.58e-142: 433: 28.29
+	Hs
		871356 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		926993 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10
+	Hs
		871354 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		909507 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10