Protein: DUS6
Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)

Gene: DUS6, DUSP6
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q16828

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703610

MK01
Mitogen-activated protein kinase 1

12

20

Small-scale

0.975

High

691761

MK03
Mitogen-activated protein kinase 3

8

20

Small-scale

0.968

High

1163832

DUS6
Dual specificity protein phosphatase 6

2

15

High-throughput

0.754

High

1163866

DUS9
Dual specificity protein phosphatase 9

2

16

High-throughput

0.754

High

1163861

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.674

High

1163876

F217B
Protein FAM217B

3

0

High-throughput

0.638

High

724757

METK2
S-adenosylmethionine synthase isoform type-2

3

1

High-throughput

0.633

High

841760

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

3

10

High-throughput

0.633

High

905581

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.618

High

1098202

DUS8
Dual specificity protein phosphatase 8

1

16

High-throughput

0.618

High

1158103

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

1163833

DUS7
Dual specificity protein phosphatase 7

1

16

High-throughput

0.618

High

1163853

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

16

High-throughput

0.618

High

1163859

AURKB
Aurora kinase B

1

3

High-throughput

0.618

High

1163869

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

8

Small-scale

0.618

High

840913

TXK
Tyrosine-protein kinase TXK

2

8

High-throughput

0.606

High

415604

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

535120

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

537242

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.571

High

582822

EZRI
Ezrin

2

1

High-throughput

0.571

High

600823

HSP76
Heat shock 70 kDa protein 6

2

4

High-throughput

0.571

High

687814

SYVC
Valine--tRNA ligase

2

3

High-throughput

0.571

High

801341

HSPA9
Stress-70 protein, mitochondrial

2

7

High-throughput

0.571

High

821375

TCPZ
T-complex protein 1 subunit zeta

2

6

High-throughput

0.571

High

899058

TCPQ
T-complex protein 1 subunit theta

2

9

High-throughput

0.571

High

899405

TCPD
T-complex protein 1 subunit delta

2

6

High-throughput

0.571

High

968718

PRS4
26S proteasome regulatory subunit 4

2

4

High-throughput

0.571

High

984633

RL39
Large ribosomal subunit protein eL39

2

1

High-throughput

0.571

High

1007037

TCPB
T-complex protein 1 subunit beta

2

4

High-throughput

0.571

High

1100808

G3BP1
Ras GTPase-activating protein-binding protein 1

2

2

High-throughput

0.571

High

1126416

CAPR1
Caprin-1

2

3

High-throughput

0.571

High

1163850

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.571

High

1163884

G3BP2
Ras GTPase-activating protein-binding protein 2

2

2

High-throughput

0.571

High

840721

RS27
Small ribosomal subunit protein eS27

2

0

High-throughput

0.547

High

899933

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.547

High

711900

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.541

High

1034248

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.541

High

1145739

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.541

High

1163844

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.536

High

1163847

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

888883

TMEDA
Transmembrane emp24 domain-containing protein 10

2

2

High-throughput

0.521

High

1163865

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

422203

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

1163880

ZN212
Zinc finger protein 212

1

2

Small-scale

0.508

High

1163843

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

1163848

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.494

High

1163849

TEX11
Testis-expressed protein 11

1

1

High-throughput

0.494

High

1163858

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.493

High

1163863

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

179518

ARPC3
Actin-related protein 2/3 complex subunit 3

1

2

High-throughput

0.479

High

323399

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

Small-scale

0.479

High

418675

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

16

High-throughput

0.479

High

467506

4F2
Amino acid transporter heavy chain SLC3A2

1

3

High-throughput

0.479

High

467919

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

2

High-throughput

0.479

High

475975

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

16

High-throughput

0.479

High

559971

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.479

High

624557

SPEE
Spermidine synthase

1

6

High-throughput

0.479

High

627342

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

857118

NSF
Vesicle-fusing ATPase

1

5

High-throughput

0.479

High

902195

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.479

High

927323

ATX1
Ataxin-1

1

4

Small-scale

0.479

High

952434

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

1

High-throughput

0.479

High

957938

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.479

High

989743

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

14

High-throughput

0.479

High

989848

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

16

High-throughput

0.479

High

1015034

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.479

High

1032480

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

2

High-throughput

0.479

High

1034449

TAGL
Transgelin

1

4

Small-scale

0.479

High

1046368

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

1098706

NDK3
Nucleoside diphosphate kinase 3

1

6

High-throughput

0.479

High

1163839

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.479

High

1163841

TRI65
E3 ubiquitin-protein ligase TRIM65

1

5

Small-scale

0.479

High

1163857

TRI11
E3 ubiquitin-protein ligase TRIM11

1

3

Small-scale

0.479

High

1163862

PARK7
Parkinson disease protein 7

1

6

High-throughput

0.479

High

1163864

CHP1
Calcineurin B homologous protein 1

1

3

High-throughput

0.479

High

1163874

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

2

High-throughput

0.479

High

1163875

AAAS
Aladin

1

2

High-throughput

0.479

High

1163878

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

10

High-throughput

0.479

High

1163879

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

1163882

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.479

High

1163883

VPS4A
Vacuolar protein sorting-associated protein 4A

1

8

High-throughput

0.479

High

1163885

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.479

High

1163887

SRPRB
Signal recognition particle receptor subunit beta

1

12

High-throughput

0.479

High

244467

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.458

High

253766

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.458

High

405293

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

1025110

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

1109283

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.458

High

1163834

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1163871

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1163872

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.458

High

257544

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

5

High-throughput

0.437

High

469089

SRPRA
Signal recognition particle receptor subunit alpha

1

2

High-throughput

0.437

High

602222

TMM11
Transmembrane protein 11, mitochondrial

1

2

High-throughput

0.437

High

698701

CALX
Calnexin

1

2

High-throughput

0.437

High

900838

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.437

High

956581

RAB5B
Ras-related protein Rab-5B

1

7

High-throughput

0.437

High

1163836

SGMR2
Sigma intracellular receptor 2

1

2

High-throughput

0.437

High

1163838

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

2

High-throughput

0.437

High

1163845

HDDC2
5'-deoxynucleotidase HDDC2

1

2

High-throughput

0.437

High

1163854

FACR1
Fatty acyl-CoA reductase 1

1

2

High-throughput

0.437

High

1163855

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.437

High

1163856

AP3S1
AP-3 complex subunit sigma-1

1

8

High-throughput

0.437

High

1163860

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.437

High

1163870

T126A
Transmembrane protein 126A

1

1

High-throughput

0.437

High

1163873

TPC
Mitochondrial thiamine pyrophosphate carrier

1

1

High-throughput

0.437

High

1163881

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.437

High

1163886

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

6

High-throughput

0.437

High

1163835

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.407

High

1163840

RL22L
Ribosomal protein eL22-like

2

0

High-throughput

0.298

High

1163851

RP9
Retinitis pigmentosa 9 protein

2

0

High-throughput

0.298

High

1163877

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

2

0

High-throughput

0.298

High

1163846

PAQR2
Adiponectin receptor protein 2

1

0

High-throughput

0.279

Low

129865

GET1
Guided entry of tail-anchored proteins factor 1

1

0

High-throughput

0.249

Low

789901

FDFT
Squalene synthase

1

0

High-throughput

0.249

Low

1163837

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.249

Low

1163842

MIC27
MICOS complex subunit MIC27

1

0

High-throughput

0.249

Low

1163852

HUMMR
Protein MGARP

1

0

High-throughput

0.249

Low

1163867

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.249

Low

1163868

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

High-throughput

0.249

Low

1163888

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025