Protein: DUS4
Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)

Gene: DUS4, DUSP4
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q13115

Gene Ontology (top 5):
GO:0001706 - endoderm formation
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703565

MK01
Mitogen-activated protein kinase 1

9

20

Small-scale

0.966

High

853669

MK08
Mitogen-activated protein kinase 8

4

20

Small-scale

0.878

High

1095028

MK14
Mitogen-activated protein kinase 14

4

20

Small-scale

0.878

High

691726

MK03
Mitogen-activated protein kinase 3

4

20

Small-scale

0.873

High

853785

MK09
Mitogen-activated protein kinase 9

3

20

High-throughput

0.843

High

1095020

DUS4
Dual specificity protein phosphatase 4

2

15

High-throughput

0.754

High

1095043

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

3

1

High-throughput

0.656

High

127945

PSD11
26S proteasome non-ATPase regulatory subunit 11

3

1

High-throughput

0.633

High

610314

PRS6A
26S proteasome regulatory subunit 6A

3

10

High-throughput

0.633

High

968897

PRS8
26S proteasome regulatory subunit 8

3

6

High-throughput

0.633

High

975387

PRS10
26S proteasome regulatory subunit 10B

3

6

High-throughput

0.633

High

912498

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

8

High-throughput

0.618

High

1095066

DS13B
Dual specificity protein phosphatase 13B

1

15

High-throughput

0.618

High

1095071

DUS12
Dual specificity protein phosphatase 12

1

15

High-throughput

0.618

High

1093802

TRAF1
TNF receptor-associated factor 1

2

3

High-throughput

0.606

High

1095037

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

1095048

LYSM1
LysM and putative peptidoglycan-binding domain-containing protein 1

2

1

High-throughput

0.606

High

1095054

ZN426
Zinc finger protein 426

2

1

High-throughput

0.606

High

1095068

NUP50
Nuclear pore complex protein Nup50

2

2

High-throughput

0.584

High

1095073

TNPO3
Transportin-3

2

9

High-throughput

0.584

High

1095046

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

123684

MYO1C
Unconventional myosin-Ic

2

14

High-throughput

0.571

High

138091

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

3

High-throughput

0.571

High

210930

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

1

High-throughput

0.571

High

227865

MYO1B
Unconventional myosin-Ib

2

15

High-throughput

0.571

High

415533

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

418655

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

16

High-throughput

0.571

High

463494

LYN
Tyrosine-protein kinase Lyn

2

8

High-throughput

0.571

High

534999

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

552569

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

2

High-throughput

0.571

High

577736

PLAK
Junction plakoglobin

2

2

High-throughput

0.571

High

587641

DESP
Desmoplakin

2

7

High-throughput

0.571

High

697511

PYR1
Multifunctional protein CAD

2

2

High-throughput

0.571

High

702101

ITPI2
Protein ITPRID2

2

1

High-throughput

0.571

High

764322

CTNA1
Catenin alpha-1

2

2

High-throughput

0.571

High

778664

PRS7
26S proteasome regulatory subunit 7

2

5

High-throughput

0.571

High

851302

PRS6B
26S proteasome regulatory subunit 6B

2

4

High-throughput

0.571

High

906511

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

2

High-throughput

0.571

High

958255

ARP2
Actin-related protein 2

2

14

High-throughput

0.571

High

984093

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

2

High-throughput

0.571

High

1050784

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

7

High-throughput

0.571

High

1095021

SRSF6
Serine/arginine-rich splicing factor 6

2

8

High-throughput

0.571

High

1095023

DSG2
Desmoglein-2

2

3

High-throughput

0.571

High

1095026

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.571

High

1095029

DREB
Drebrin

2

4

High-throughput

0.571

High

1095036

CCAR2
Cell cycle and apoptosis regulator protein 2

2

2

High-throughput

0.571

High

1095040

HS105
Heat shock protein 105 kDa

2

9

High-throughput

0.571

High

1095052

PKP2
Plakophilin-2

2

2

High-throughput

0.571

High

1095058

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

2

High-throughput

0.571

High

1095059

GID8
Glucose-induced degradation protein 8 homolog

2

4

High-throughput

0.571

High

1095062

TECR
Very-long-chain enoyl-CoA reductase

2

2

High-throughput

0.571

High

1095063

SYLC
Leucine--tRNA ligase, cytoplasmic

2

3

High-throughput

0.571

High

1095064

GBG12

2

1

High-throughput

0.571

High

1095069

COR1C
Coronin-1C

2

6

High-throughput

0.571

High

1095070

G3BP2
Ras GTPase-activating protein-binding protein 2

2

2

High-throughput

0.571

High

1095034

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

2

1

High-throughput

0.553

High

1095053

LZTS2
Leucine zipper putative tumor suppressor 2

2

12

High-throughput

0.553

High

1095056

PKHF2
Pleckstrin homology domain-containing family F member 2

2

2

High-throughput

0.553

High

1095057

GORS2
Golgi reassembly-stacking protein 2

2

2

High-throughput

0.553

High

1095022

DX39B
Spliceosome RNA helicase DDX39B

2

0

High-throughput

0.547

High

1095027

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

0

High-throughput

0.547

High

1095060

LYAR
Cell growth-regulating nucleolar protein

2

0

High-throughput

0.547

High

1095041

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1095067

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

415144

AMYP
Pancreatic alpha-amylase

2

6

High-throughput

0.521

High

627095

AMY2B
Alpha-amylase 2B

2

2

High-throughput

0.521

High

687795

SYVC
Valine--tRNA ligase

2

3

High-throughput

0.521

High

1095025

PLEC
Plectin

2

3

High-throughput

0.521

High

1095061

TMOD3
Tropomodulin-3

2

5

High-throughput

0.521

High

422027

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

123376

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

2

High-throughput

0.479

High

532556

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

680858

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

681153

PSA2
Proteasome subunit alpha type-2

1

2

High-throughput

0.479

High

700875

PSB4
Proteasome subunit beta type-4

1

2

High-throughput

0.479

High

701142

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

1095074

MTCH2
Mitochondrial carrier homolog 2

1

5

High-throughput

0.479

High

716282

PRDX6
Peroxiredoxin-6

1

3

High-throughput

0.479

High

716423

PRDX5
Peroxiredoxin-5, mitochondrial

1

3

High-throughput

0.479

High

837216

ACTY
Beta-centractin

1

17

High-throughput

0.479

High

841714

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

10

High-throughput

0.479

High

907406

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

927272

ATX1
Ataxin-1

1

5

Small-scale

0.479

High

986387

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

995951

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

3

High-throughput

0.479

High

1095030

RN187
E3 ubiquitin-protein ligase RNF187

1

3

High-throughput

0.479

High

1095038

NUD10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

1

2

High-throughput

0.479

High

1095042

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.479

High

1095044

ABHEB
Putative protein-lysine deacylase ABHD14B

1

2

High-throughput

0.479

High

1095045

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

8

High-throughput

0.479

High

1095047

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1095049

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

5

High-throughput

0.479

High

1095050

PARK7
Parkinson disease protein 7

1

5

High-throughput

0.479

High

1095055

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

1095072

TR150
Thyroid hormone receptor-associated protein 3

1

2

High-throughput

0.479

High

1095024

DPYL1
Dihydropyrimidinase-related protein 1

1

2

High-throughput

0.464

High

681356

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

785823

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.458

High

1095032

NXN
Nucleoredoxin

1

0

High-throughput

0.458

High

1095031

H37
Histone H3-7

1

1

High-throughput

0.445

High

624555

SPEE
Spermidine synthase

1

5

High-throughput

0.437

High

724056

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.437

High

906399

DHB4
Peroxisomal multifunctional enzyme type 2

1

3

High-throughput

0.437

High

1026008

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.437

High

1095039

AP3S1
AP-3 complex subunit sigma-1

1

7

High-throughput

0.437

High

1095065

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.437

High

517221

AMY1B
Alpha-amylase 1B

1

2

High-throughput

0.407

High

1095033

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.316

High

389738

FETUA
Alpha-2-HS-glycoprotein

2

0

High-throughput

0.298

High

569181

CD59
CD59 glycoprotein

2

0

High-throughput

0.298

High

596567

EPCAM
Epithelial cell adhesion molecule

2

0

High-throughput

0.298

High

1095035

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.298

High

1095051

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025