HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: CUL7 (Q14999)
Cullin-7 (CUL-7)
Gene: CUL7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	27705803, 33961781, 31343991, 12481031, 17998335, 23045529, 12904573
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031467 - Cul7-RING ubiquitin ligase complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 163 Hs			1 1698
+	Mm
		1257554 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		CUL7_MOUSE (1-1698): 0: 2813: 76.45
+	Hs
		928979 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL9_HUMAN (1-782): 0: 910: 45.71