Protein: SEC18
Vesicular-fusion protein SEC18

Gene: SEC18
Organism: Saccharomyces cerevisiae S288C
Interactions: 109
UniProt ID: P18759

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000149 - SNARE binding
GO:0005524 - ATP binding
GO:0005794 - Golgi apparatus
GO:0005795 - Golgi stack

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

616382

SEC18
Vesicular-fusion protein SEC18

2

18

Small-scale

0.781

High

616398

HS104
Heat shock protein 104

2

5

High-throughput

0.754

High

616465

RPN5
26S proteasome regulatory subunit RPN5

2

7

High-throughput

0.694

High

616449

GCN5
Histone acetyltransferase GCN5

1

11

High-throughput

0.691

High

616403

SEC17
Alpha-soluble NSF attachment protein

4

10

Small-scale

0.683

High

616419

RPN1
26S proteasome regulatory subunit RPN1

2

6

High-throughput

0.675

High

616432

COPB2
Coatomer subunit beta'

3

6

High-throughput

0.670

High

616464

VAM3
Syntaxin VAM3

3

17

Small-scale

0.651

High

616434

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

9

High-throughput

0.640

High

616410

SPT7
SAGA complex subunit SPT7

1

6

High-throughput

0.618

High

616392

CDC48
Cell division control protein 48

1

17

High-throughput

0.618

High

616408

PRS7
26S proteasome regulatory subunit 7 homolog

1

20

High-throughput

0.618

High

616428

PRS4
26S proteasome regulatory subunit 4 homolog

1

13

High-throughput

0.618

High

616437

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

616451

RPN9
26S proteasome regulatory subunit RPN9

2

3

High-throughput

0.601

High

616384

TRX1
Thioredoxin-1

2

11

Small-scale

0.595

High

616431

MAD2
Mitotic spindle checkpoint component MAD2

1

1

High-throughput

0.587

High

578802

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

616383

SEC22
Protein transport protein SEC22

2

7

Small-scale

0.584

High

616414

YKT6
Synaptobrevin homolog YKT6

2

7

Small-scale

0.584

High

616420

RPN10
26S proteasome regulatory subunit RPN10

2

2

High-throughput

0.584

High

616391

MAS5
Mitochondrial protein import protein MAS5

2

5

High-throughput

0.571

High

616388

PSA2
Proteasome subunit alpha type-2

1

13

High-throughput

0.553

High

616453

RPN7
26S proteasome regulatory subunit RPN7

1

5

High-throughput

0.553

High

616415

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.536

High

616436

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.536

High

616400

EI2BB
Translation initiation factor eIF2B subunit beta

1

4

High-throughput

0.508

High

616444

IMA1
Importin subunit alpha

1

3

High-throughput

0.508

High

616386

TRX2
Thioredoxin-2

1

9

Small-scale

0.501

High

616406

VAM7
Vacuolar morphogenesis protein 7

1

3

Small-scale

0.501

High

616407

YPT7
Ypt/Rab-type GTPase YPT7

1

7

Small-scale

0.501

High

314837

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.493

High

616416

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.486

High

616445

MUK1
Protein MUK1

1

0

High-throughput

0.486

High

510953

IPB2
Protease B inhibitor 2

1

0

Small-scale

0.480

High

383502

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.479

High

392192

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.479

High

409922

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

433431

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

434801

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435756

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

454856

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

502834

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.479

High

504024

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

514440

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

518193

IF4A
ATP-dependent RNA helicase eIF4A

1

8

High-throughput

0.479

High

616385

VPS34
Phosphatidylinositol 3-kinase VPS34

1

8

High-throughput

0.479

High

616387

BET1
Protein transport protein BET1

1

6

Small-scale

0.479

High

616389

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

616393

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

616396

SEC1
Protein transport protein SEC1

1

5

High-throughput

0.479

High

616397

SNC1
Synaptobrevin homolog 1

1

11

Small-scale

0.479

High

616404

PEP12
Syntaxin PEP12

1

20

Small-scale

0.479

High

616405

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

616409

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

616413

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

616417

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

616424

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

616429

SEC9
Protein transport protein SEC9

1

1

High-throughput

0.479

High

616430

SEC24
Protein transport protein SEC24

1

4

High-throughput

0.479

High

616435

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.479

High

616438

MSO1
Protein MSO1

1

1

High-throughput

0.479

High

616442

SED5
Integral membrane protein SED5

1

20

Small-scale

0.479

High

616443

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

616446

BECN1
Vacuolar protein sorting-associated protein 30

1

2

High-throughput

0.479

High

616450

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

616452

SYRC
Arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

616456

SUB2
ATP-dependent RNA helicase SUB2

1

9

High-throughput

0.479

High

616458

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.479

High

616459

AP3D
AP-3 complex subunit delta

1

9

High-throughput

0.479

High

616460

MLH3
DNA mismatch repair protein MLH3

1

2

High-throughput

0.479

High

616461

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.479

High

616462

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

616467

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

616468

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.479

High

616422

MET30
F-box protein MET30

1

10

High-throughput

0.464

High

616440

CAF40
Protein CAF40

1

2

High-throughput

0.464

High

616390

BOS1
Protein transport protein BOS1

1

0

Small-scale

0.458

High

525869

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

616402

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

616427

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

150256

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.437

High

380955

H2B1
Histone H2B.1

1

8

High-throughput

0.437

High

381389

H2B2
Histone H2B.2

1

8

High-throughput

0.437

High

419351

H2A1
Histone H2A.1

1

4

High-throughput

0.437

High

419585

H2A2
Histone H2A.2

1

4

High-throughput

0.437

High

616395

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

616399

RPN12
26S proteasome regulatory subunit RPN12

1

2

High-throughput

0.437

High

616401

RPN2
26S proteasome regulatory subunit RPN2

1

6

High-throughput

0.437

High

616418

ECM29
Proteasome component ECM29

1

9

High-throughput

0.437

High

616425

RPN3
26S proteasome regulatory subunit RPN3

1

5

High-throughput

0.437

High

616433

UFE1
Syntaxin UFE1

1

1

High-throughput

0.437

High

616439

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

3

High-throughput

0.437

High

616441

H3
Histone H3

1

6

High-throughput

0.437

High

616447

ESP1
Separin

1

1

High-throughput

0.437

High

616448

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.437

High

616454

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

616455

ATG23
Autophagy-related protein 23

1

1

High-throughput

0.437

High

616457

RPN8
26S proteasome regulatory subunit RPN8

1

4

High-throughput

0.437

High

616463

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

616466

RPN6
26S proteasome regulatory subunit RPN6

1

4

High-throughput

0.437

High

616469

CMR1
DNA damage-binding protein CMR1

1

8

High-throughput

0.437

High

616421

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

616423

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.407

High

616426

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

6

High-throughput

0.407

High

616394

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

616411

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

616412

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025