Protein: NSF
Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)

Gene: NSF
Organism: Homo sapiens
Interactions: 238
UniProt ID: P46459

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001921 - positive regulation of receptor recycling
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

857070

SNAA
Alpha-soluble NSF attachment protein

6

10

Small-scale

0.950

High

857163

SNAG
Gamma-soluble NSF attachment protein

3

14

High-throughput

0.871

High

857060

NSF
Vesicle-fusing ATPase

2

18

Small-scale

0.755

High

241015

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

857090

EP300
Histone acetyltransferase p300

2

7

High-throughput

0.754

High

225951

STX6
Syntaxin-6

4

7

High-throughput

0.699

High

857140

STX12
Syntaxin-12

4

16

High-throughput

0.697

High

857170

ASPC1
Tether containing UBX domain for GLUT4

1

9

Small-scale

0.680

High

838479

GRIA2
Glutamate receptor 2

3

4

Small-scale

0.678

High

189449

STX7
Syntaxin-7

3

17

High-throughput

0.667

High

395657

ESR1
Estrogen receptor

3

13

Small-scale

0.641

High

857176

RBSK
Ribokinase

3

0

High-throughput

0.634

High

278480

VAMP4
Vesicle-associated membrane protein 4

2

6

High-throughput

0.628

High

331844

GOSR1
Golgi SNAP receptor complex member 1

2

1

High-throughput

0.628

High

857147

SCFD1
Sec1 family domain-containing protein 1

2

5

High-throughput

0.628

High

857197

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

5

High-throughput

0.628

High

857202

STX8
Syntaxin-8

2

9

High-throughput

0.628

High

529298

TAU
Microtubule-associated protein tau

3

8

High-throughput

0.624

High

320635

UBXN7
UBX domain-containing protein 7

1

20

High-throughput

0.618

High

857200

UBQL2
Ubiquilin-2

1

8

High-throughput

0.618

High

857095

STX5
Syntaxin-5

2

19

High-throughput

0.611

High

857099

CUL3
Cullin-3

2

10

High-throughput

0.611

High

179838

BET1
BET1 homolog

3

7

High-throughput

0.599

High

857122

MIDN
Midnolin

1

0

High-throughput

0.586

High

345493

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

7

High-throughput

0.584

High

857069

RAB9A
Ras-related protein Rab-9A

2

10

High-throughput

0.584

High

857080

RHOB
Rho-related GTP-binding protein RhoB

2

17

High-throughput

0.584

High

857071

TERA
Transitional endoplasmic reticulum ATPase

1

18

High-throughput

0.575

High

296856

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

4

Small-scale

0.573

High

857191

PLK2
Serine/threonine-protein kinase PLK2

1

8

Small-scale

0.573

High

857196

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

4

Small-scale

0.561

High

857131

BCOR
BCL-6 corepressor

1

7

High-throughput

0.553

High

124006

SNP23
Synaptosomal-associated protein 23

1

8

High-throughput

0.536

High

130031

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.536

High

158139

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.536

High

160246

GOSR2
Golgi SNAP receptor complex member 2

1

5

High-throughput

0.536

High

160873

STX16
Syntaxin-16

1

15

High-throughput

0.536

High

178735

SCAM1
Secretory carrier-associated membrane protein 1

1

2

High-throughput

0.536

High

178917

SCAM2
Secretory carrier-associated membrane protein 2

1

2

High-throughput

0.536

High

249832

STX10
Syntaxin-10

1

8

High-throughput

0.536

High

280150

SC22B
Vesicle-trafficking protein SEC22b

1

7

High-throughput

0.536

High

328643

VAMP5
Vesicle-associated membrane protein 5

1

7

High-throughput

0.536

High

343328

SNP29
Synaptosomal-associated protein 29

1

8

High-throughput

0.536

High

384381

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.536

High

421685

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.536

High

591415

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

1

High-throughput

0.536

High

606089

DESM
Desmin

1

11

High-throughput

0.536

High

746184

STX2
Syntaxin-2

1

17

High-throughput

0.536

High

773441

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.536

High

857062

GNPI1
Glucosamine-6-phosphate deaminase 1

1

2

High-throughput

0.536

High

857068

RAB7A
Ras-related protein Rab-7a

1

8

High-throughput

0.536

High

857078

RAB14
Ras-related protein Rab-14

1

11

High-throughput

0.536

High

857081

RAB1A
Ras-related protein Rab-1A

1

6

High-throughput

0.536

High

857082

VAMP2
Vesicle-associated membrane protein 2

1

9

High-throughput

0.536

High

857083

BT3A2
Butyrophilin subfamily 3 member A2

1

2

High-throughput

0.536

High

857096

STX3
Syntaxin-3

1

16

High-throughput

0.536

High

857114

VAMP3
Vesicle-associated membrane protein 3

1

8

High-throughput

0.536

High

857144

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.536

High

857153

RAB24
Ras-related protein Rab-24

1

8

High-throughput

0.536

High

857154

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

5

High-throughput

0.536

High

857164

GPA33
Cell surface A33 antigen

1

3

High-throughput

0.536

High

857166

VAMP8
Vesicle-associated membrane protein 8

1

8

High-throughput

0.536

High

857169

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

857172

RAB1B
Ras-related protein Rab-1B

1

4

High-throughput

0.536

High

857180

GORS2
Golgi reassembly-stacking protein 2

1

1

High-throughput

0.536

High

857184

RTN4
Reticulon-4

1

1

High-throughput

0.536

High

857190

BET1L
BET1-like protein

1

6

High-throughput

0.536

High

857195

STX18
Syntaxin-18

1

3

High-throughput

0.536

High

857203

AKT3
RAC-gamma serine/threonine-protein kinase

1

6

High-throughput

0.536

High

857209

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

2

High-throughput

0.536

High

428082

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.518

High

857073

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.518

High

134595

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.515

High

599560

STMN1
Stathmin

1

3

High-throughput

0.515

High

642698

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.515

High

857158

SENP8
Sentrin-specific protease 8

1

2

High-throughput

0.515

High

137199

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.513

High

857100

GALE
UDP-glucose 4-epimerase

1

0

High-throughput

0.513

High

857104

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.513

High

857108

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.513

High

857112

TSN
Translin

1

0

High-throughput

0.513

High

857151

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

857155

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

857189

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

857206

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

857205

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.494

High

303112

RGS20
Regulator of G-protein signaling 20

1

0

High-throughput

0.493

High

857105

CRYM
Ketimine reductase mu-crystallin

1

0

High-throughput

0.493

High

857175

TPK1
Thiamine pyrophosphokinase 1

1

0

High-throughput

0.493

High

848988

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

12

Small-scale

0.489

High

857072

FOXA3
Hepatocyte nuclear factor 3-gamma

1

1

High-throughput

0.489

High

857093

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.489

High

857094

SEC20
Vesicle transport protein SEC20

1

1

High-throughput

0.489

High

857098

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

857161

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.489

High

857171

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.489

High

260845

RAMP3
Receptor activity-modifying protein 3

1

0

Small-scale

0.480

High

125303

LEG9
Galectin-9

1

1

High-throughput

0.479

High

157067

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

192995

CFLAR
CASP8 and FADD-like apoptosis regulator

1

4

High-throughput

0.479

High

217940

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

349856

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

362947

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

373825

RASN
GTPase NRas

1

13

High-throughput

0.479

High

374455

RASH
GTPase HRas

1

12

High-throughput

0.479

High

375271

RASK
GTPase KRas

1

13

High-throughput

0.479

High

411544

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

458321

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

466142

RHOC
Rho-related GTP-binding protein RhoC

1

15

High-throughput

0.479

High

474535

VIME
Vimentin

1

12

High-throughput

0.479

High

528211

THIO
Thioredoxin

1

12

Small-scale

0.479

High

536701

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

540349

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

541388

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

562998

MYH6
Myosin-6

1

3

High-throughput

0.479

High

574079

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

6

High-throughput

0.479

High

601205

RHOQ
Rho-related GTP-binding protein RhoQ

1

16

High-throughput

0.479

High

710680

EPHA8
Ephrin type-A receptor 8

1

3

High-throughput

0.479

High

713935

PML
Protein PML

1

8

High-throughput

0.479

High

728100

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

728928

PUR9
Bifunctional purine biosynthesis protein ATIC

1

1

High-throughput

0.479

High

731059

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

766288

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

798818

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

830300

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

857061

MAP1B
Microtubule-associated protein 1B

1

6

High-throughput

0.479

High

857063

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

857065

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.479

High

857067

5HT6R
5-hydroxytryptamine receptor 6

1

2

Small-scale

0.479

High

857075

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.479

High

857076

RAB4B
Ras-related protein Rab-4B

1

11

High-throughput

0.479

High

857077

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

857079

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

857084

RHOG
Rho-related GTP-binding protein RhoG

1

13

High-throughput

0.479

High

857085

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

857088

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

9

High-throughput

0.479

High

857091

STX4
Syntaxin-4

1

16

High-throughput

0.479

High

857097

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

857106

IMB1
Importin subunit beta-1

1

7

High-throughput

0.479

High

857109

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

857113

RHOH
Rho-related GTP-binding protein RhoH

1

17

High-throughput

0.479

High

857115

NTRK3
NT-3 growth factor receptor

1

9

High-throughput

0.479

High

857116

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.479

High

857118

DUS6
Dual specificity protein phosphatase 6

1

5

High-throughput

0.479

High

857119

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

857120

GRDN
Girdin

1

13

High-throughput

0.479

High

857121

LARP7
La-related protein 7

1

8

High-throughput

0.479

High

857125

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

857129

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

857130

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

857132

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

857134

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

857136

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

857138

WAPL
Wings apart-like protein homolog

1

1

High-throughput

0.479

High

857139

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

Small-scale

0.479

High

857143

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

857148

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

857152

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

857159

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

857160

SCLT1
Sodium channel and clathrin linker 1

1

10

High-throughput

0.479

High

857173

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

857177

RHOJ
Rho-related GTP-binding protein RhoJ

1

16

High-throughput

0.479

High

857178

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

857179

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

857182

RHOF
Rho-related GTP-binding protein RhoF

1

19

High-throughput

0.479

High

857183

NEK6
Serine/threonine-protein kinase Nek6

1

6

High-throughput

0.479

High

857185

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

857187

DUS22
Dual specificity protein phosphatase 22

1

4

High-throughput

0.479

High

857193

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

857198

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

857199

TBK1
Serine/threonine-protein kinase TBK1

1

5

High-throughput

0.479

High

857211

KC1G3
Casein kinase I isoform gamma-3

1

7

High-throughput

0.479

High

857126

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

376750

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

785808

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

857086

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

857142

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

857207

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

857210

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

456097

FES
Tyrosine-protein kinase Fes/Fps

1

3

Small-scale

0.445

High

471735

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

9

High-throughput

0.445

High

597886

FER
Tyrosine-protein kinase Fer

1

2

Small-scale

0.445

High

635834

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

2

High-throughput

0.445

High

658815

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

10

High-throughput

0.445

High

659001

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

12

High-throughput

0.445

High

722412

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.445

High

779696

MOT8
Monocarboxylate transporter 8

1

5

High-throughput

0.445

High

857074

SNP25
Synaptosomal-associated protein 25

1

8

Small-scale

0.445

High

857087

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

857089

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

16

High-throughput

0.445

High

857092

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

11

High-throughput

0.445

High

857101

BECN1
Beclin-1

1

2

High-throughput

0.445

High

857110

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

9

High-throughput

0.445

High

857117

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

9

High-throughput

0.445

High

857123

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

857124

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.445

High

857127

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

857137

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

1

High-throughput

0.445

High

857174

S12A5
Solute carrier family 12 member 5

1

1

High-throughput

0.445

High

857186

S17A5
Sialin

1

4

High-throughput

0.445

High

857204

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

857066

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

105527

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

192464

INSI1
Insulin-induced gene 1 protein

1

2

High-throughput

0.437

High

247732

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

324627

HEXI1
Protein HEXIM1

1

2

High-throughput

0.437

High

588137

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

606393

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

694859

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

698469

CALX
Calnexin

1

4

High-throughput

0.437

High

767635

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

857064

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

857102

RBM39
RNA-binding protein 39

1

7

High-throughput

0.437

High

857107

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

6

High-throughput

0.437

High

857133

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

857146

DUS19
Dual specificity protein phosphatase 19

1

5

High-throughput

0.437

High

857149

ESR2
Estrogen receptor beta

1

12

High-throughput

0.437

High

857150

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.437

High

857162

RING2
E3 ubiquitin-protein ligase RING2

1

8

High-throughput

0.437

High

857165

PCGF1
Polycomb group RING finger protein 1

1

6

High-throughput

0.437

High

857181

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.437

High

857128

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

857141

SL9A9
Sodium/hydrogen exchanger 9

1

0

High-throughput

0.426

High

857145

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

653179

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

857103

MFS10
Major facilitator superfamily domain-containing protein 10

1

4

High-throughput

0.407

High

857192

USE1
Vesicle transport protein USE1

1

1

Small-scale

0.407

High

857168

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.282

High

857194

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

857201

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

857156

REEP6
Receptor expression-enhancing protein 6

1

0

High-throughput

0.279

Low

857167

F174C
Protein FAM174C

1

0

High-throughput

0.279

Low

857208

SALL2
Sal-like protein 2

1

0

High-throughput

0.279

Low

857111

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

857135

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.249

Low

857157

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.249

Low

857188

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025