HitPredict

Interactor 1: PDI (P54399)
Protein disulfide-isomerase (PDI) (dPDI) (EC 5.3.4.1)
Gene: PDI

Interactor 2: TRXR1 (P91938)
Thioredoxin reductase 1, mitochondrial (EC 1.8.1.9)
Gene: TRXR1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pyr_redox_2~Thioredoxin, Pyr_redox_dim~Thioredoxin
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 496 Dm			1 596
+	Dm
		1019584 Q3YMU0_DROME (3-490): 4.36e-107: 329: 32.13		TRXR1_DROME (1-596): 0: 607: 100.00
+	Dm
		929600 PDI_DROME (1-496): 4.34e-144: 424: 100.00		Q9VVL7_DROME (95-589): 1.01e-139: 417: 25.50
+	Dm
		1191731 Q3YMU0_DROME (3-490): 4.36e-107: 329: 32.13		Q9VVL7_DROME (95-589): 1.01e-139: 417: 25.50
+	Dm
		1019614 Q95TL8_DROME (362-493): 3.07e-24: 106: 22.46		TRXR1_DROME (1-596): 0: 607: 100.00
+	Dm
		1019629 PDIA6_DROME (372-461): 5.99e-10: 63.2: 36.67		TRXR1_DROME (1-596): 0: 607: 100.00
+	Hs
		1142284 PDIA6_HUMAN (372-461): 5.64e-09: 60.1: 35.56		TRXR1_HUMAN (17-595): 2.6e-168: 495: 48.38
+	Hs
		484540 PDIA6_HUMAN (372-461): 5.64e-09: 60.1: 35.56		DLDH_HUMAN (86-589): 3.83e-145: 431: 25.05
+	Dm
		1465301 PDIA6_DROME (372-461): 5.99e-10: 63.2: 36.67		Q9VVL7_DROME (95-589): 1.01e-139: 417: 25.50