Protein: TRXR1
Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)

Gene: TRXR1, TXNRD1
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q16881

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001707 - mesoderm formation
GO:0004791 - thioredoxin-disulfide reductase (NADPH) activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142284

PDIA6
Protein disulfide-isomerase A6

4

7

High-throughput

0.895

High

1164377

TRXR2
Thioredoxin reductase 2, mitochondrial

2

15

High-throughput

0.789

High

291655

XRP2
Protein XRP2

4

0

High-throughput

0.661

High

1164379

GLRX2
Glutaredoxin-2, mitochondrial

1

4

Small-scale

0.647

High

396220

ESR1
Estrogen receptor

2

3

Small-scale

0.624

High

1164326

CDO1
Cysteine dioxygenase type 1

2

0

High-throughput

0.602

High

1164368

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

16

Small-scale

0.575

High

1164374

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

2

High-throughput

0.541

High

281329

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.536

High

533292

THA
Thyroid hormone receptor alpha

1

1

Small-scale

0.527

High

1164372

ESR2
Estrogen receptor beta

1

3

Small-scale

0.527

High

529898

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

1164381

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.513

High

1041092

CAV1
Caveolin-1

1

2

Small-scale

0.512

High

478909

PO2F2
POU domain, class 2, transcription factor 2

1

1

Small-scale

0.501

High

576236

PO2F1
POU domain, class 2, transcription factor 1

1

1

Small-scale

0.501

High

241834

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

412014

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

413934

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

425529

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

508056

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

520095

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

588821

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

695594

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

697130

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.479

High

768318

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

830833

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

934688

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

957406

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

1138264

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1150390

NCOA2
Nuclear receptor coactivator 2

1

1

Small-scale

0.479

High

1164369

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1164373

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

1164376

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1164380

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

260028

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

651351

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

891593

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

954696

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

1106558

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1164382

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1164383

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1164375

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

353365

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

1164371

SHKB1
SH3KBP1-binding protein 1

1

1

High-throughput

0.437

High

886913

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

1164370

DMRTD
Doublesex- and mab-3-related transcription factor C2

1

0

High-throughput

0.282

High

246294

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.249

Low

1136645

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

1164378

VCX3
Variable charge X-linked protein 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025