HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17643375
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~TIP49
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane GO:0035267 - NuA4 histone acetyltransferase complex and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 456
+	Hs
		892123 ACTB_HUMAN (1-375): 0: 604: 98.93		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		932463 ACTC_HUMAN (2-375): 0: 595: 94.39		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Dm
		501453 ACT5_DROME (2-375): 0: 598: 95.46		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		892121 ACTB_HUMAN (1-375): 0: 604: 98.93		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		930057 ACTG_HUMAN (1-375): 0: 604: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		932462 ACTC_HUMAN (2-375): 0: 595: 94.39		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		887667 ACT_YEAST (1-375): 0: 592: 89.07		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		887725 ACT_YEAST (1-375): 0: 592: 89.07		RUVB2_YEAST (5-455): 0: 627: 41.72